ArticleAJNR. American journal of neuroradiology2010
Improvement in angiographic cerebral vasospasm after intra-arterial verapamil administration.
Article in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 44 citations in OpenAlex.
- Vasospasm following resection of olfactory groove meningiomas via orbitozygomatic craniotomy: illustrative cases.Journal of neurosurgery. Case lessons · 2025Article
- Article
- Beyond nimodipine: advanced neuroprotection strategies for aneurysmal subarachnoid hemorrhage vasospasm and delayed cerebral ischemia.Neurosurgical review · 2024Review
- Treatment of Cerebral Vasospasm With Continuous Intra-Arterial Nimodipine: A Case Report.Cureus · 2022Article
- Duration of Vasodilatory Action After Intra-arterial Infusions of Calcium Channel Blockers in Animal Model of Cerebral Vasospasm.Neurocritical care · 2021Article
- Treatment of postoperative vasospasm with intraarterial verapamil after removal of intracranial tumor: patient series.Journal of neurosurgery. Case lessons · 2021Article
- Intra-Arterial Verapamil Treatment in Oral Therapy-Refractory Reversible Cerebral Vasoconstriction Syndrome.AJNR. American journal of neuroradiology · 2020Article
- Intra-arterial verapamil post-thrombectomy is feasible, safe, and neuroprotective in stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Aneurysmal Subarachnoid Hemorrhage.Journal of neurosurgical anesthesiology · 2015Review
- High risk of new episode of symptomatic vasospasm in unaffected arteries in subarachnoid hemorrhage patients receiving targeted endovascular treatment for symptomatic focal vasospasm.Neurocritical care · 2014Article
- [Intra-arterial injection of verapamil in treatment of cerebral vasospasm in a patient with acute subarachnoid hemorrhage from an aneurysm: case report].Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko · 2013Article
- Reversible cerebral vasoconstriction syndrome: an important cause of acute severe headache.Emergency medicine international · 2012Article
- High-dose intra-arterial nicardipine results in hypotension following vasospasm treatment in subarachnoid hemorrhage.Neurocritical care · 2011Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeEndovascular options for therapy for patients with vasospasm after SAH include angioplasty and intra-arterial vasodilator infusion. Preliminary studies of the effects of the calcium channel antagonist verapamil on angiographic vasospasm have yielded mixed and/or qualitative results. In this study, improvement in angiographic vasospasm after intra-arterial verapamil administration is demonstrated with quantitative, blinded methods. MATERIALS AND
methodsThis retrospective observational case series includes 12 patients with vasospasm after SAH who collectively received 16 treatments with intra-arterial verapamil during a 2-year period at our institution. The exclusion criterion was concurrent treatment with angioplasty. Blinded reviewers quantitatively evaluated angiograms from each patient and/or treatment after presentation with SAH and before and after intra-arterial treatment of vasospasm.
resultsPatients were treated with intra-arterial verapamil for vasospasm 9 ± 4 days after SAH with a range from 1 to 16 days. For the 34 arterial distributions treated, the segment with the worst angiographic vasospasm from each arterial distribution averaged 51 ± 13% stenosis, which improved to 29 ± 18% stenosis (P < .001). There was no significant difference in treatment effect in proximal arterial segments, which may be amenable to angioplasty, compared with distal segments (P > .05). There was no significant difference in treatment effect in arterial segments previously subjected to angioplasty compared with other segments (P > .05).
conclusionsIntra-arterially administered verapamil improves angiographic vasospasm after SAH when administered at 10 ± 3 mg per arterial distribution. Optimal dose, infusion rate, and retreatment interval remain to be determined. Randomized controlled trials are needed to prove efficacy in the treatment of clinical vasospasm.
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