ArticleDevelopmental and comparative immunology2010
Comparative analyses of B cell populations in trout kidney and mouse bone marrow: establishing "B cell signatures".
Article in Developmental and comparative immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Divergent B-cell repertoire remodelling by mRNA, DNA and live attenuated vaccines in fish.NPJ vaccines · 2025Article
- Immunological memory in a teleost fish: common carp IgMFrontiers in immunology · 2024Article
- Endoplasmic reticulum expansion throughout the differentiation of teleost B cells to plasmablasts.iScience · 2023Article
- Transcriptome Analysis Indicates Immune Responses againstAnimals : an open access journal from MDPI · 2022Article
- Teleost fish IgMFrontiers in immunology · 2022Article
- Article
- Innate immune cell signatures in a BCWD-Resistant line of rainbow trout before and after in vivo challenge with Flavobacterium psychrophilum.Developmental and comparative immunology · 2019Article
- Sequential Immunization With Heterologous Viruses Does Not Result in Attrition of the B Cell Memory in Rainbow Trout.Frontiers in immunology · 2019Article
- Melanomacrophages and melanomacrophage centres inCentral-European journal of immunology · 2019Review
- Specific humoral immunity inCentral-European journal of immunology · 2018Review
- A BCWD-resistant line of rainbow trout exhibits higher abundance of IgTDevelopmental and comparative immunology · 2017Article
- B cells and their role in the teleost gut.Developmental and comparative immunology · 2016Review
- Mucosal Immunity and B Cells in Teleosts: Effect of Vaccination and Stress.Frontiers in immunology · 2015Review
- Alternative splicing of the trout Pax5 gene and identification of novel B cell populations using Pax5 signatures.Developmental and comparative immunology · 2013Article
- Sockeye salmon retain immunoglobulin-secreting plasma cells throughout their spawning journey and post-spawning.Developmental and comparative immunology · 2013Article
- Teleost fish mount complex clonal IgM and IgT responses in spleen upon systemic viral infection.PLoS pathogens · 2013Article
- Defining terminally differentiating B cell populations in rainbow trout immune tissues using the transcription factor XbpI.Fish & shellfish immunology · 2011Article
- Dissecting teleost B cell differentiation using transcription factors.Developmental and comparative immunology · 2011Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
This study aimed to identify the frequency and distribution of developing B cell populations in the kidney of the rainbow trout, using four molecular B cell markers that are highly conserved between species, including two transcription factors, Pax5 and EBF1, recombination-activating gene RAG1, and the immunoglobulin heavy chain mu. Three distinct B cell stages were defined: early developing B cells (CLP, pro-B, and early pre-B cells), late developing B cell (late pre-B, immature B, and mature B cells), and IgM-secreting cells. Developmental stage-specific, combinatorial expression of Pax5, EBF1, RAG1 and immunoglobulin mu was determined in trout anterior kidney cells by flow cytometry. Trout staining patterns were compared to a well-defined primary immune tissue, mouse bone marrow, and using mouse surface markers B220 and CD43. A remarkable level of similarity was uncovered between the primary immune tissues of both species. Subsequent analysis of the entire trout kidney, divided into five contiguous segments K1-K5, revealed a complex pattern of early developing, late developing, and IgM-secreting B cells. Patterns in anterior kidney segment K1 were most similar to those of mouse bone marrow, while the most posterior part of the kidney, K5, had many IgM-secreting cells, but lacked early developing B cells. A potential second B lymphopoiesis site was uncovered in segment K4 of the kidney. The B cell patterns, or "B cell signatures" described here provide information on the relative abundance of distinct developing B cell populations in the trout kidney, and can be used in future studies on B cell development in other vertebrate species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.