ArticleZhongguo fei ai za zhi = Chinese journal of lung cancer2010
[Expression and significance of MTA2 in non-small cell lung cancer].
Article in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 4 citations in OpenAlex.
- Review
- Expression of P120 catenin, Kaiso, and metastasis tumor antigen-2 in thymomas.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Expression of metastasis-associated protein 2 (MTA2) might predict proliferation in non-small cell lung cancer.Targeted oncology · 2012Article
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6 authors at 1 institution in 1 country.
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Abstract
BACKGROUND AND
objectiveIt has been proven that MTA2 was expressed in many tumor cell lines and was correlated with tumor invasion and metastasis. The aim of this study is to investigate the expression of MTA2 protein in non-small cell lung cancer (NSCLC) and to explore the relationship between the expression of MTA2 and the pathological features.
methodsThe expression of MTA2 protein in 110 cases of NSCLC and 34 cases corresponding lung tissues was detected with immunohistochemistry method. The relationship between the expression of MTA2 and the pathological features in NSCLC was analyzed statistically.
resultsThere was no expression of MTA2 protein in cancer collateral branch trachea epithelial and alveolar epithelial, but there was some expression in partial NSCLC. The positive rate of MTA2 was 58.18% (64/110) in 110 NSCLC cases. The expression of MTA2 had negative correlation with differentiation degree of NSCLC but had positive correlation with clinical stage and lymph node metastasis (P<0.05), moreover, it had no obvious correlation with age, gender and pathological type (P>0.05).
conclusionThere was some expression of MTA2 in partial NSCLC and it was correlated with differentiation degree, clinical stage and lymph node metastasis. The results show that the occurrence and development of lung cancer may be related with MTA2. MTA2 may act as a new symbol and target in the treatment of lung cancer.
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