ArticleBMC systems biology2010
Modeling the global effect of the basic-leucine zipper transcription factor 1 (bZIP1) on nitrogen and light regulation in Arabidopsis.
Article in BMC systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Physiological and Molecular Mechanisms of Nitrogen Regulation on Grain Quality in Cereal Crops at Later Stages.International journal of molecular sciences · 2026Review
- Modelling the short-term response to nitrogen that coordinates events in lateral root initiation.Quantitative plant biology · 2026Article
- Shining light on Arabidopsis regulatory networks integrating nitrogen use and photosynthesis.The Plant journal : for cell and molecular biology · 2025Article
- Genome-Wide Analysis of C/S1-bZIP Subfamilies inInternational journal of molecular sciences · 2024Article
- Transcriptome Profiling Reveals the Gene Network Responding to Low Nitrogen Stress in Wheat.Plants (Basel, Switzerland) · 2024Article
- Article
- Genetic variation underlying differential ammonium and nitrate responses in Arabidopsis thaliana.The Plant cell · 2022Article
- Positive selection and heat-response transcriptomes reveal adaptive features of the Brassicaceae desert model, Anastatica hierochuntica.The New phytologist · 2022Article
- Evaluation ofFrontiers in plant science · 2022Article
- GARP transcription factors repress Arabidopsis nitrogen starvation response via ROS-dependent and -independent pathways.Journal of experimental botany · 2021Article
- Genome-Wide Systematic Characterization of theInternational journal of molecular sciences · 2020Article
- TheFrontiers in plant science · 2020Article
- WRKY1 Mediates Transcriptional Regulation of Light and Nitrogen Signaling Pathways.Plant physiology · 2019Article
- Article
- Transcriptome Analysis in Chinese Cabbage (Brassica rapa ssp. pekinensis) Provides the Role of Glucosinolate Metabolism in Response to Drought Stress.Molecules (Basel, Switzerland) · 2018Article
- Article
- Integrative Transcriptomic Analysis Uncovers Novel Gene Modules That Underlie the Sulfate Response inFrontiers in plant science · 2018Article
- Changes in Gene Expression in Space and Time Orchestrate Environmentally Mediated Shaping of Root Architecture.The Plant cell · 2017Article
- Nitrate signaling and early responses in Arabidopsis roots.Journal of experimental botany · 2017Review
- "Hit-and-Run" transcription: de novo transcription initiated by a transient bZIP1 "hit" persists after the "run".BMC genomics · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundNitrogen and light are two major regulators of plant metabolism and development. While genes involved in the control of each of these signals have begun to be identified, regulators that integrate gene responses to nitrogen and light signals have yet to be determined. Here, we evaluate the role of bZIP1, a transcription factor involved in light and nitrogen sensing, by exposing wild-type (WT) and bZIP1 T-DNA null mutant plants to a combinatorial space of nitrogen (N) and light (L) treatment conditions and performing transcriptome analysis. We use ANOVA analysis combined with clustering and Boolean modeling, to evaluate the role of bZIP1 in mediating L and N signaling genome-wide.
resultsThis transcriptome analysis demonstrates that a mutation in the bZIP1 gene can alter the L and/or N-regulation of several gene clusters. More surprisingly, the bZIP1 mutation can also trigger N and/or L regulation of genes that are not normally controlled by these signals in WT plants. This analysis also reveals that bZIP1 can, to a large extent, invert gene regulation (e.g., several genes induced by N in WT plants are repressed by N in the bZIP1 mutant).
conclusionThese findings demonstrate that the bZIP1 mutation triggers a genome-wide de-regulation in response to L and/or N signals that range from i) a reduction of the L signal effect, to ii) unlocking gene regulation in response to L and N combinations. This systems biology approach demonstrates that bZIP1 tunes L and N signaling relationships genome-wide, and can suppress regulatory mechanisms hypothesized to be needed at different developmental stages and/or environmental conditions.
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