ArticleBehavioral and brain functions : BBF2010
Association study between a polymorphism at the 3'-untranslated region of CLOCK gene and attention deficit hyperactivity disorder.
Article in Behavioral and brain functions : BBF, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 97 citations in OpenAlex.
- Cortical morphometric inverse divergence in attention-deficit/hyperactivity disorder correlates with cell-type-specific, laminar-specific and developmental transcriptomic signatures.Psychological medicine · 2026Article
- Circadian clock genes and insomnia: molecular mechanisms and therapeutic implications.Annals of medicine · 2025Review
- The Role of mRNA Alternative Processing in Mammalian Neurodevelopment.International journal of molecular sciences · 2025Review
- Circadian Regulation of Neuronal Membrane Capacitance-Mechanisms and Implications for Neural Computation and Behavior.International journal of molecular sciences · 2025Review
- Circadian rhythms and neuroendocrine dysregulation in ADHD: Therapeutic insights from omega-3 fatty acids.BioMedicine · 2025Review
- Association between CLOCK gene polymorphisms and ADHD in Mexican teenagers: A comprehensive assessment.Psychiatry research · 2022Article
- Krüppel-like factor 7 deficiency causes autistic-like behavior in mice via regulating Clock gene.Cell & bioscience · 2022Article
- Clock Genes Profiles as Diagnostic Tool in (Childhood) ADHD-A Pilot Study.Brain sciences · 2022Article
- Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications.Nutrients · 2021Review
- The Role of the Circadian System in Attention Deficit Hyperactivity Disorder.Advances in experimental medicine and biology · 2021Review
- Sleep and Microbiome in Psychiatric Diseases.Nutrients · 2020Review
- [Adult attention deficit hyperactivity disorder and comorbidity: new findings on epidemiological and genetic factors].Der Nervenarzt · 2020Review
- Polymorphic Appetite Effects on Waist Circumference Depend on rs3749474 CLOCK Gene Variant.Nutrients · 2020Article
- Sleep and Circadian Medicine: Time of Day in the Neurologic Clinic.Neurologic clinics · 2019Review
- Impact of adult attention deficit hyperactivity disorder and medication status on sleep/wake behavior and molecular circadian rhythms.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Genome-wide identification and expression analyses of WRKY transcription factor family members from chickpea (Cicer arietinum L.) reveal their role in abiotic stress-responses.Genes & genomics · 2019Article
- Article
- Common and specific genes and peripheral biomarkers in children and adults with attention-deficit/hyperactivity disorder.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2018Review
- Sleep, chronotype, and sleep hygiene in children with attention-deficit/hyperactivity disorder, autism spectrum disorder, and controls.European child & adolescent psychiatry · 2018Article
- Correcting delayed circadian phase with bright light therapy predicts improvement in ADHD symptoms: A pilot study.Journal of psychiatric research · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThe circadian locomotor output cycles kaput (CLOCK) gene encodes protein regulation circadian rhythm and also plays some roles in neural transmitter systems including the dopamine system. Several lines of evidence implicate a relationship between attention-deficit hyperactivity disorder (ADHD), circadian rythmicity and sleeping disturbances. A recent study has reported that a polymorphism (rs1801260) at the 3'-untranslated region of the CLOCK gene is associated with adult ADHD.
methodsTo investigate the association between the polymorphism (rs1801260) in ADHD, two samples of ADHD probands from the United Kingdom (n = 180) and Taiwan (n = 212) were genotyped and analysed using within-family transmission disequilibrium test (TDT). Bonferroni correction procedures were used to just for multiple comparisons.
resultsWe found evidence of increased transmission of the T allele of the rs1801260 polymorphism in Taiwanese samples (P = 0.010). There was also evidence of preferential transmission of the T allele of the rs1801260 polymorphism in combined samples from the Taiwan and UK (P = 0.008).
conclusionThis study provides evidence for the possible involvement of CLOCK in susceptibility to ADHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.