ArticlePharmaceutical research2010
Beta-casein nanoparticles as an oral delivery system for chemotherapeutic drugs: impact of drug structure and properties on co-assembly.
Article in Pharmaceutical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 118 citations in OpenAlex.
- Biopolymeric nanocarriers in cancer therapy: unleashing the potency of bioactive anticancer compounds for enhancing drug delivery.RSC advances · 2024Review
- Preparation, Optimization, and Anti-Pulmonary Infection Activity of Casein-Based Chrysin Nanoparticles.International journal of nanomedicine · 2024Article
- Casein-Based Nanoparticles: A Potential Tool for the Delivery of Daunorubicin in Acute Lymphocytic Leukemia.Pharmaceutics · 2023Article
- Article
- Optimization and Formulation of Nanostructured and Self-Assembled Caseinate Micelles for Enhanced Cytotoxic Effects of Paclitaxel on Breast Cancer Cells.Pharmaceutics · 2020Article
- Dextran-Curcumin Nanoparticles as a Methotrexate Delivery Vehicle: A Step Forward in Breast Cancer Combination Therapy.Pharmaceuticals (Basel, Switzerland) · 2019Article
- Approaches in Polymeric Nanoparticles for Vaginal Drug Delivery: A Review of the State of the Art.International journal of molecular sciences · 2018Review
- Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends.International journal of nanomedicine · 2018Review
- Ovomucin nanoparticles: promising carriers for mucosal delivery of drugs and bioactive compounds.Drug delivery and translational research · 2017Article
- Potential of Casein as a Carrier for Biologically Active Agents.Topics in current chemistry (Cham) · 2017Review
- Production of Recombinant Antimicrobial Polymeric Protein Beta Casein-E 50-52 and Its Antimicrobial Synergistic Effects Assessment with Thymol.Molecules (Basel, Switzerland) · 2017Article
- Hyaluronic acid-serum albumin conjugate-based nanoparticles for targeted cancer therapy.Oncotarget · 2017Article
- Article
- Cytotoxic and antiangiogenic paclitaxel solubilized and permeation-enhanced by natural product nanoparticles.Anti-cancer drugs · 2015Article
- Investigation of magnetically controlled water intake behavior of Iron Oxide Impregnated Superparamagnetic Casein Nanoparticles (IOICNPs).Journal of nanobiotechnology · 2014Article
- Micellar delivery of flutamide via milk protein nanovehicles enhances its anti-tumor efficacy in androgen-dependent prostate cancer rat model.Pharmaceutical research · 2013Article
- Novel spray-dried genipin-crosslinked casein nanoparticles for prolonged release of alfuzosin hydrochloride.Pharmaceutical research · 2013Article
- Novel ionically crosslinked casein nanoparticles for flutamide delivery: formulation, characterization, and in vivo pharmacokinetics.International journal of nanomedicine · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo develop a novel oral drug delivery system comprising a hydrophobic chemotherapeutic drug entrapped within beta casein (β-CN), a major milk protein, which self-associates into micelles in aqueous solutions. The efficient gastric digestibility of β-CN suggests possible targeting to gastric cancers.
methodsAntitumor drug entrapment was performed by stirring its dimethyl-sulfoxide solution into a phosphate-buffered saline containing β-CN. The association of drugs to β-CN was characterized by spectrophotometry and Trp143 fluorescence quenching; particle-size by dynamic light scattering, and colloidal stability by zeta potential.
resultsThe optimal drug-to-β-CN molar loading-ratios for paclitaxel and vinblastine at 1 mg/ml β-CN were found to be 7.3 ± 1.2 and 5.3 ± 0.6 and the association constants were (6.3 ± 1.0) x 10(3) M(-1) and (2.0 ± 0.3) x 10(4) M(-1), respectively. Zeta potential analysis suggested that nanoencapsulation by β-CN stabilized all studied drugs in aqueous solution. The initial drug-β-CN association was apparently governed by hydrophobic interactions and at higher drug concentrations, also by electrostatic interactions. Up to the optimal drug:β-CN loading-ratio, ~80% of the particles were below 100 nm in diameter. At higher drug concentrations, particle diameter increased, and bi- or tri-modal particle distributions were observed.
conclusionsBeta-CN forms colloidally-stable nanovehicles of hydrophobic anticancer drugs, and may be used for oral-delivery of chemotherapeutics.
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