ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2010
Ocular manifestations of syphilis: recent cases over a 2.5-year period.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 86 citations in OpenAlex.
- Syphilitic Uveitis: Clinical Features, Treatment, and Outcome.The American journal of case reports · 2025Article
- Comparative evaluation of long-term ophthalmic sequelae following first versus second-line antibiotic treatment for congenital syphilis.International journal of retina and vitreous · 2025Article
- Could ceftriaxone be a viable alternative to penicillin for the treatment of ocular syphilis?Antimicrobial agents and chemotherapy · 2024Article
- Secondary syphilis presenting with non-arteritic anterior ischemic optic neuropathy (NAION).Oxford medical case reports · 2024Article
- Article
- [Ocular syphilis associated to HIV: A report of 2 patients treated in Marrakech, Morocco].Medecine tropicale et sante internationale · 2022Article
- Demographic, Clinical and Laboratory Characteristics of Ocular Syphilis: 6-Years Case Series Study From an Eye Center in East-China.Frontiers in immunology · 2022Article
- Older woman with abdominal pain and bilateral sequential vision loss due to syphilis.BMJ case reports · 2021Article
- Syphilis Laboratory Guidelines: Performance Characteristics of Nontreponemal Antibody Tests.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Review
- Syphilitic uveitis misdiagnosed as viral retinitis-a misleading history.Journal of ophthalmic inflammation and infection · 2018Article
- Recent Updates on Treatment of Ocular Microbial Infections by Stem Cell Therapy: A Review.International journal of molecular sciences · 2018Review
- Increase in Ocular Syphilis Cases at Ophthalmologic Reference Center, France, 2012-2015.Emerging infectious diseases · 2018Article
- Repeat Intravitreal Dexamethasone Implant for Refractory Cystoid Macular Edema in Syphilitic Uveitis.Case reports in ophthalmological medicine · 2018Article
- Clinical manifestations and treatment outcomes of syphilitic uveitis in HIV-negative patients in China: A retrospective case study.Medicine · 2017Article
- Non-human Immunodeficiency Virus-related Ocular Syphilis in a Korean Population: Clinical Manifestations and Treatment Outcomes.Korean journal of ophthalmology : KJO · 2016Article
- Clinical manifestations and cerebrospinal fluid status in ocular syphilis in HIV-Negative patients.BMC infectious diseases · 2016Article
- Syphilitic Optic Neuropathy: Re-emerging Cases Over a 2-Year Period.Neuro-ophthalmology (Aeolus Press) · 2016Article
- Syphilitic uveitis as the presenting feature of HIV.Indian journal of ophthalmology · 2016Article
- OCULAR SYPHILIS IN A KIDNEY TRANSPLANT RECIPIENT.Revista do Instituto de Medicina Tropical de Sao Paulo · 2016Article
- Severe acute syphilitic posterior placoid chorioretinitis with complete spontaneous resolution: The natural course.GMS ophthalmology cases · 2016Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ocular manifestations of syphilis are protean and can affect every structure of the eye. There has been a recent increase of syphilis infection in Europe. We report recent cases of ocular syphilis infection in a tertiary center.
methodsDuring a 2.5-year period (2005-2007) we collected the medical records of eight male patients with ocular syphilis. The diagnosis was based on serological tests on blood samples and cerebrospinal fluid. All patients underwent a check-up to rule out another etiological diagnosis and to detect the presence of any other sexually transmitted infections.
resultsThe ocular lesions included: chorioretinitis (one case), retinitis (two cases), panuveitis with macular edema (two cases), episcleritis (one case), anterior optic neuritis (one case), and retrobulbar optic neuropathy (one case). Infection of the cerebrospinal fluid was detected in three of the five patients tested. In six cases, the inflammation was unilateral, and the anatomical and functional prognosis was excellent at the 6-month follow-up visit. Co-infection with human immunodeficiency virus was reported in five patients, with a CD4 T lymphocyte count greater than 300/mm(3). Most of the patients were treated with parenteral ceftriaxone (1 g daily) for 3 weeks with good tolerance. One patient was treated with intravenous penicillin G (18 MUI daily). Only one patient with anterior optic neuritis required systemic steroid therapy associated with antibiotics. Sequelae included sectorial atrophy of the optic nerve with visual field loss (n = 1) and abnormalities of the retinal pigment epithelium (n = 3).
conclusionsAll patients with ocular syphilis exhibited functional improvement and resolution of ocular inflammation after a specific antibiotic treatment. As a great imitator, syphilis should be considered in all patients with uveitis, scleritis, episcleritis, or optic neuritis, especially in men with high-risk sexual behavior.
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