ArticleWorld journal of surgery2010
Clinical implication of the number of central lymph node metastasis in papillary thyroid carcinoma: preliminary report.
Article in World journal of surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer.Thyroid : official journal of the American Thyroid Association · 2025Guideline
- Value of sentinel lymph node biopsy in papillary thyroid cancer: initial results of a prospective trial.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2015Trial
- Machine Learning: A Multicenter Study on Predicting Lateral Lymph Node Metastasis in cN0 Papillary Thyroid Carcinoma.The Journal of clinical endocrinology and metabolism · 2025Article
- Killing capacity analysis of tumor-infiltrating cytotoxic lymphocytes and impact on lymph node metastasis in differentiated papillary carcinoma of thyroid with the BRAF V600E mutation.Diagnostic pathology · 2024Article
- Distinct risk factors of lateral lymph node metastasis in patients with papillary thyroid cancer based on age stratification.BMC surgery · 2024Article
- Should multifocality be an indication for prophylactic central neck dissection in papillary thyroid cancer?Updates in surgery · 2023Article
- Prospective application of a prediction model for lateral lymph node metastasis in papillary thyroid cancer patients with central lymph node metastasis.Frontiers in endocrinology · 2023Article
- Predictive Factors Affecting the Development of Central Lymph Node Metastasis in Papillary Thyroid Cancer.Sisli Etfal Hastanesi tip bulteni · 2022Article
- Ultrasound lymphatic imaging for the diagnosis of metastatic central lymph nodes in papillary thyroid cancer.European radiology · 2021Article
- Risk Factors and a Prediction Model of Lateral Lymph Node Metastasis in CN0 Papillary Thyroid Carcinoma Patients With 1-2 Central Lymph Node Metastases.Frontiers in endocrinology · 2021Article
- Risk Factors of Central Lymph Node Metastasis in Papillary Thyroid Microcarcinoma and the Value of Sentinel Lymph Node Biopsy.Frontiers in surgery · 2021Article
- A rare case showing an enlarged level I lymph node as the first symptom due to papillary thyroid microcarcinoma.Gland surgery · 2020Article
- Risk model and risk stratification to preoperatively predict central lymph node metastasis in papillary thyroid carcinoma.Gland surgery · 2020Article
- The LINC01186 suppresses cell proliferation and invasion ability in papillary thyroid carcinoma.Oncology letters · 2018Article
- CUNR scoring system for the prediction of lateral lymph node metastasis in papillary thyroid carcinoma.Oncotarget · 2018Article
- Significance of micrometastases in the calculation of the lymph node ratio for papillary thyroid cancer.Annals of surgical treatment and research · 2017Article
- Practice patterns among thyroid cancer surgeons: implications of performing a prophylactic central neck dissection.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2016Article
- Risk factors analyses for lateral lymph node metastases in papillary thyroid carcinomas: a retrospective study of 356 patients.Archives of endocrinology and metabolism · 2016Article
- Bilaterality weighs more than unilateral multifocality in predicting prognosis in papillary thyroid cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Metastatic Lymph Node Ratio of Central Neck Compartment Has Predictive Values for Locoregional Recurrence in Papillary Thyroid Microcarcinoma.Clinical and experimental otorhinolaryngology · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPapillary thyroid cancer (PTC) metastasizes to central lymph node (CLN). CLN metastasis is associated with high risk of locoregional recurrence and distant metastasis. The significance of the number of metastatic CLN has not been addressed. This study was designed to evaluate the clinical implication of the number of metastatic CLN in PTC.
methodsWe reviewed the patients who underwent total thyroidectomy and CLN dissection with or without lateral neck dissection due to PTC, from March 2008 to June 2009. The relationships between the number of CLN and risk factors, including age, gender, tumor size, extrathyroidal extension, and lateral lymph node metastasis, were assessed. Patients were divided into three groups according to the number of CLN: group A = 0; group B = 1-2; and group C = ≥3.
resultsOf 258 patients enrolled in this study, 113 were in group A, 73 in group B, and 72 in group C. Extrathyroidal extension and lateral neck lymph node metastasis were related to increased rate of CLN metastasis (P < 0.05). Tumor size increased as the number of CLN increased; group C had the largest tumor size (P < 0.05). When evaluating the distribution of patients with extrathyroidal extension, group C had a significant odds ratio (4.213, P < 0.05). When evaluating the distribution of lateral neck lymph node metastasis, groups B and C had significant odds ratio (14.353, 75.403, respectively, P < 0.05).
conclusionsThe number of CLN metastasis correlated with the negative prognostic factors, including tumor size, extrathyroidal extension, and lateral neck lymph node metastasis. This suggests that the number of CLN has prognostic implication.
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