Evidence map›Paper›PMID 20702755›Full record

SynthesisThe Annals of pharmacotherapy2010

Predictors of nonadherence to statins: a systematic review and meta-analysis.

Devin M Mann, Mark Woodward, Paul Muntner, Louise Falzon, Ian Kronish

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Annals of pharmacotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Genetic factors affecting statin concentrations and subsequent myopathy: a HuGENet systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2014
    Pooled it
  8. Trial
  9. Trial
  10. Impact of Educational Attainment on Health Outcomes in Moderate to Severe CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Trial
  11. Trial
  12. Trial
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Devin M MannDivision of General Internal Medicine, Mount Sinai School of Medicine, New York, NY, USA. devin.mann@mssm.edu
Mark Woodward
Paul Muntner
Louise Falzon
Ian Kronish

Funding

Diabetes Risk Communication Tool to Improve Lifestyle BehaviorsK23DK081665 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MANN, DEVIN M · 2009 to 2013
$875k
Uncontrolled hypertension - the role of medication adherence and clinical inertiaK23HL098359 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRONISH, IAN MATTHEW · 2010 to 2014
$688k
NHLBI NIH HHS K23 HL098359NIDDK NIH HHS 1K23DK081665NIDDK NIH HHS K23 DK081665
6 · The paper itself

Abstract

backgroundNonadherence to statins limits the benefits of this common drug class. Individual studies assessing predictors of nonadherence have produced inconsistent results.

objectiveTo identify reliable predictors of nonadherence to statins through systematic review and meta-analysis.

methodsMultiple databases, including MEDLINE, EMBASE, and PsycINFO, were searched (from inception through February 2009) to identify studies that evaluated predictors of nonadherence to statins. Studies were selected using a priori defined criteria, and each study was reviewed by 2 authors who abstracted data on study characteristics and outcomes. Relative risks were then pooled, using an inverse-variance weighted random-effects model.

resultsTwenty-two cohort studies met inclusion criteria. Age had a U-shaped association with adherence; the oldest (>/=70 years) and youngest (<50 years) subjects had lower adherence than the middle-aged (50-69 years) subjects. Women and patients with lower incomes were more likely to be nonadherent than were men (odds of nonadherence 1.07; 95% CI 1.04 to 1.11) and those with higher incomes (odds of nonadherence 1.18; 95% CI 1.10 to 1.28), respectively. A history of cardiovascular disease predicted better adherence to statins (odds of nonadherence 0.68; 95% CI 0.66 to 0.78). Similarly, a diagnosis of hypertension or diabetes was associated with better adherence. Although there were too few studies for quantitative pooling, increased testing of lipid levels and lower out-of-pocket costs appeared to be associated with better adherence. There was substantial (I(2) range 68.7-96.3%) heterogeneity between studies across factors.

conclusionsSeveral sociodemographic, medical, and health-care utilization characteristics are associated with statin nonadherence. These factors may be useful guides for targeting statin adherence interventions.

Indexed as

Age FactorsCardiovascular DiseasesCohort StudiesComorbidityDiabetes MellitusHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypertensionPatient ComplianceSocioeconomic FactorsHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID20702755
PMCPMC3641194

What OpenQuestion holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.