ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Sensory input drives multiple intracellular information streams in somatosensory cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Information transfer and recovery for the sense of touch.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Propofol-mediated Unconsciousness Disrupts Progression of Sensory Signals through the Cortical Hierarchy.Journal of cognitive neuroscience · 2024Article
- Millisecond precision temporal encoding of stimulus features during cortically generated gamma oscillations in the rat somatosensory cortex.The Journal of physiology · 2018Article
- Multiplexed Spike Coding and Adaptation in the Thalamus.Cell reports · 2017Article
- Estimating the Information Extracted by a Single Spiking Neuron from a Continuous Input Time Series.Frontiers in computational neuroscience · 2017Article
- Distinct Corticostriatal and Intracortical Pathways Mediate Bilateral Sensory Responses in the Striatum.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Dendritic nonlinearities are tuned for efficient spike-based computations in cortical circuits.eLife · 2015Article
- Reading spike timing without a clock: intrinsic decoding of spike trains.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Sensory experience modifies spontaneous state dynamics in a large-scale barrel cortical model.Journal of computational neuroscience · 2012Article
- Three-dimensional axon morphologies of individual layer 5 neurons indicate cell type-specific intracortical pathways for whisker motion and touch.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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4 authors.
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Abstract
Stable perception arises from the interaction between sensory inputs and internal activity fluctuations in cortex. Here we analyzed how different types of activity contribute to cortical sensory processing at the cellular scale. We performed whole-cell recordings in the barrel cortex of anesthetized rats while applying ongoing whisker stimulation and measured the information conveyed about the time-varying stimulus by different types of input (membrane potential) and output (spiking) signals. We found that substantial, comparable amounts of incoming information are carried by two types of membrane potential signal: slow, large (up-down state) fluctuations, and faster (>20 Hz), smaller-amplitude synaptic activity. Both types of activity fluctuation are therefore significantly driven by the stimulus on an ongoing basis. Each stream conveys essentially independent information. Output (spiking) information is contained in spike timing not just relative to the stimulus but also relative to membrane potential fluctuations. Information transfer is favored in up states relative to down states. Thus, slow, ongoing activity fluctuations and finer-scale synaptic activity generate multiple channels for incoming and outgoing information within barrel cortex neurons during ongoing stimulation.
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