ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Intralaminar and interlaminar activity within the rodent superior colliculus visualized with voltage imaging.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Neuronal Features of Visual Attention in the Mouse Superior Colliculus Depend on Learned Behavioral Relevance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Dopamine modulates visual threat processing in the superior colliculus via D2 receptors.iScience · 2022Article
- Unraveling circuits of visual perception and cognition through the superior colliculus.Neuron · 2021Review
- Sensorimotor transformation elicits systematic patterns of activity along the dorsoventral extent of the superior colliculus in the macaque monkey.Communications biology · 2019Article
- Instantaneous Midbrain Control of Saccade Velocity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Integrating Brain and Biomechanical Models-A New Paradigm for Understanding Neuro-muscular Control.Frontiers in neuroscience · 2018Article
- Circuits for Action and Cognition: A View from the Superior Colliculus.Annual review of vision science · 2017Review
- A sodium afterdepolarization in rat superior colliculus neurons and its contribution to population activity.Journal of neurophysiology · 2016Article
- A hard-wired priority map in the superior colliculus shaped by asymmetric inhibitory circuitry.Journal of neurophysiology · 2015Article
- Response normalization in the superficial layers of the superior colliculus as a possible mechanism for saccadic averaging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Excitatory synaptic feedback from the motor layer to the sensory layers of the superior colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Nanotools for neuroscience and brain activity mapping.ACS nano · 2013Review
- The relative impact of microstimulation parameters on movement generation.Journal of neurophysiology · 2012Article
- Article
- Order of operations for decoding superior colliculus activity for saccade generation.Journal of neurophysiology · 2011Article
- Circuit dynamics of the superior colliculus revealed by in vitro voltage imaging.Annals of the New York Academy of Sciences · 2011Article
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3 authors.
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Abstract
The superior colliculus (SC) is a midbrain structure that plays a role in converting sensation into action. Most SC research focuses on either in vivo extracellular recordings from behaving monkeys or patch-clamp recordings from smaller mammals in vitro. However, the activity of neuronal circuits is necessary to generate behavior, and neither of these approaches measures the simultaneous activity of large populations of neurons that make up circuits. Here, we describe experiments in which we measured changes in membrane potential across the SC map using voltage imaging of the rat SC in vitro. Our results provide the first high temporal and spatial resolution images of activity within the SC. Electrical stimulation of the SC evoked a characteristic two-component optical response containing a short latency initial-spike and a longer latency after-depolarization. Single-pulse stimulation in the superficial SC evoked a pattern of intralaminar and interlaminar spread that was distinct from the spread evoked by the same stimulus applied to the intermediate SC. Intermediate layer stimulation produced a more extensive and more ventrally located activation of the superficial layers than did stimulation in the superficial SC. Together, these results indicate the recruitment of dissimilar subpopulations of circuitry depending on the layer stimulated. Field potential recordings, pharmacological manipulations, and timing analyses indicate that the patterns of activity were physiologically relevant and largely synaptically driven. Therefore, voltage imaging is a powerful technique for the study of spatiotemporal dynamics of electrical signaling across neuronal populations, providing insight into neural circuits that underlie behavior.
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