ArticleJournal of the Royal Society, Interface2011
Response dynamics of phosphorelays suggest their potential utility in cell signalling.
Article in Journal of the Royal Society, Interface, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- EvgS/EvgA, the unorthodox two-component system regulating bacterial multiple resistance.Applied and environmental microbiology · 2023Review
- A theoretical framework to analyse the flow of particles in a dynamical system with stochastic transition rates and site capacities.Royal Society open science · 2022Article
- Systematic analysis of noise reduction properties of coupled and isolated feed-forward loops.PLoS computational biology · 2021Article
- A Radical Reimagining of Fungal Two-Component Regulatory Systems.Trends in microbiology · 2021Review
- Maximization of information transmission influences selection of native phosphorelay architectures.PeerJ · 2021Article
- The Signaling Molecule Indole Inhibits Induction of the AR2 Acid Resistance System inFrontiers in microbiology · 2020Article
- Structural and Functional Analysis of the Escherichia coli Acid-Sensing Histidine Kinase EvgS.Journal of bacteriology · 2017Article
- Optimal Down Regulation of mRNA Translation.Scientific reports · 2017Article
- A deterministic mathematical model for bidirectional excluded flow with Langmuir kinetics.PloS one · 2017Article
- Arabidopsis response regulator 22 inhibits cytokinin-regulated gene transcription in vivo.Protoplasma · 2017Article
- Phosphoryl Group Flow within the Pseudomonas aeruginosa Pil-Chp Chemosensory System: DIFFERENTIAL FUNCTION OF THE EIGHT PHOSPHOTRANSFERASE AND THREE RECEIVER DOMAINS.The Journal of biological chemistry · 2016Article
- Article
- Phosphate sink containing two-component signaling systems as tunable threshold devices.PLoS computational biology · 2014Article
- Characterization of mutations in the PAS domain of the EvgS sensor kinase selected by laboratory evolution for acid resistance in Escherichia coli.Molecular microbiology · 2014Article
- Stochastic flux analysis of chemical reaction networks.BMC systems biology · 2013Article
- Simplifying biochemical models with intermediate species.Journal of the Royal Society, Interface · 2013Article
- Split histidine kinases enable ultrasensitivity and bistability in two-component signaling networks.PLoS computational biology · 2013Article
- Phosphorelays provide tunable signal processing capabilities for the cell.PLoS computational biology · 2013Article
- Article
- Bayesian design of synthetic biological systems.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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3 authors.
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Abstract
Phosphorelays are extended two-component signalling systems found in diverse bacteria, lower eukaryotes and plants. Only few of these systems are characterized, and we still lack a full understanding of their signalling abilities. Here, we aim to achieve a global understanding of phosphorelay signalling and its dynamical properties. We develop a generic model, allowing us to systematically analyse response dynamics under different assumptions. Using this model, we find that the steady-state concentration of phosphorylated protein at the final layer of a phosphorelay is a linearly increasing, but eventually saturating function of the input. In contrast, the intermediate layers can display ultrasensitivity. We find that such ultrasensitivity is a direct result of the phosphorelay biochemistry; shuttling of a single phosphate group from the first to the last layer. The response dynamics of the phosphorelay results in tolerance of cross-talk, especially when it occurs as cross-deactivation. Further, it leads to a high signal-to-noise ratio for the final layer. We find that a relay length of four, which is most commonly observed, acts as a saturating point for these dynamic properties. These findings suggest that phosphorelays could act as a mechanism to reduce noise and effects of cross-talk on the final layer of the relay and enforce its input-response relation to be linear. In addition, our analysis suggests that middle layers of phosphorelays could embed thresholds. We discuss the consequence of these findings in relation to why cells might use phosphorelays along with enzymatic kinase cascades.
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