ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2010
New method to measure and improve consistency of baroreflex sensitivity values.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Acute right-sided transcutaneous vagus nerve stimulation improves cardio-vagal baroreflex gain in patients with chronic heart failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Trial
- Effects of Experimental Sleep Restriction on Ambulatory and Sleep Blood Pressure in Healthy Young Adults: A Randomized Crossover Study.Hypertension (Dallas, Tex. : 1979) · 2021Trial
- Suspension syndrome: a potentially fatal vagally mediated circulatory collapse-an experimental randomized crossover trial.European journal of applied physiology · 2019Trial
- Constant hepatic ATP concentrations during prolonged fasting and absence of effects of Cerbomed NemosMolecular metabolism · 2018Trial
- Oxygen-induced impairment in arterial function is corrected by slow breathing in patients with type 1 diabetes.Scientific reports · 2017Trial
- Effects of a single bout of interval hypoxia on cardiorespiratory control and blood glucose in patients with type 2 diabetes.Diabetes care · 2013Trial
- Effect of simulated microgravity via head-down tilt on intracranial compliance, brain oscillations and cardiovascular autonomic modulation.Scientific reports · 2025Article
- Treating heart failure by targeting the vagus nerve.Heart failure reviews · 2024Review
- Both Hypoxia and Hypobaria Impair Baroreflex Sensitivity but through Different Mechanisms.International journal of sports medicine · 2023Article
- Article
- Persons with type 1 diabetes have low blood oxygen levels in the supine and standing body positions.BMJ open diabetes research & care · 2021Article
- AltitudeOmics: Spontaneous Baroreflex Sensitivity During Acclimatization to 5,260 m: A Comparison of Methods.Frontiers in physiology · 2019Article
- Mental Workload Alters Heart Rate Variability, Lowering Non-linear Dynamics.Frontiers in physiology · 2019Article
- The Effect of Lower-Body Positive Pressure on the Cardiorespiratory Response at Rest and during Submaximal Running Exercise.Frontiers in physiology · 2018Article
- AltitudeOmics: Baroreflex Sensitivity During Acclimatization to 5,260 m.Frontiers in physiology · 2018Article
- An Innovative Technique to Assess Spontaneous Baroreflex Sensitivity with Short Data Segments: Multiple Trigonometric Regressive Spectral Analysis.Frontiers in physiology · 2018Article
- Validity and variability of xBRS: instantaneous cardiac baroreflex sensitivity.Physiological reports · 2017Article
- Integrated Cardio-Respiratory Control: Insight in Diabetes.Current diabetes reports · 2016Review
- Multipotent adult progenitor cells for hypoxic-ischemic injury in the preterm brain.Journal of neuroinflammation · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBaroreflex sensitivity (BRS) is an important prognostic index in cardiovascular diseases, however, its use is complicated by different methods difficult to compare and standardize, often providing conflicting results. We tested whether the simple ratio of RR interval to systolic blood pressure global variabilities (assessed by standard deviations) is a reliable measure of BRS, by measuring the agreement with six established methods. In addition, we tested whether high-pass filtering of data, by removing slow non-baroreflex-mediated fluctuations, could improve the agreement between different BRS methods.
methodsIn 1,409 subjects, we compared 6 established methods (derived by cross-spectral and sequence analysis) and the new method, supine and in response to tilting (1,175 subjects). Data were analyzed after linear detrending, high-pass filtering at 0.025 and 0.05 Hz.
resultsAlthough all seven methods showed a general agreement, the new method consistently showed the lowest distance from the median of the remaining methods (0.04 ± 0.06 ms/mmHg over 2,584 files, p < 0.05 with respect to the second best method). High-pass filtering improved (p < 0.001) the agreement between methods without reducing the sensitivity to changes induced by tilting. Only the new method could provide estimates in all 2,584 files tested.
interpretationThe new method intercepts the mean information of all other methods better than any other method, hence providing a simple, easy to standardize (no mathematical constraints) and yet robust and reliable BRS estimate. High-pass filtering markedly improves the agreement of all methods, without loss of sensitivity, and could be routinely used in clinical trials, to provide comparable BRS estimates.
Indexed as
Identifiers
20700641What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.