ArticleJournal of neural transmission (Vienna, Austria : 1996)2010
Neuroprotective effect of Spirulina in cerebral ischemia-reperfusion injury in rats.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Therapeutic potential of spirulina and its bioactive compound phycocyanin in neuropsychiatric disorders.Molecular biology reports · 2026Review
- The effect ofSurgical neurology international · 2024Article
- Cyanobacteria and Algal-Based Biological Life Support System (BLSS) and Planetary Surface Atmospheric Revitalizing Bioreactor Brief Concept Review.Life (Basel, Switzerland) · 2023Review
- Spirulina platensis protects against microcystin-LR-induced toxicity in rats.Environmental science and pollution research international · 2022Article
- Spirulina Microalgae and Brain Health: A Scoping Review of Experimental and Clinical Evidence.Marine drugs · 2021Article
- A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer's Pathogenesis-And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder.International journal of molecular sciences · 2021Review
- C-Phycocyanin-derived Phycocyanobilin as a Potential Nutraceutical Approach for Major Neurodegenerative Disorders and COVID-19- induced Damage to the Nervous System.Current neuropharmacology · 2021Article
- Protective Effects ofNeuropsychiatric disease and treatment · 2020Article
- Therapeutic Effects ofJournal of experimental pharmacology · 2020Article
- Potential Neuroprotective Treatment of Stroke: Targeting Excitotoxicity, Oxidative Stress, and Inflammation.Frontiers in neuroscience · 2019Review
- Impact of Early High-protein Diet on Neurofunctional Recovery in Rats with Ischemic Stroke.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Sustained Effects of Neonatal Systemic Lipopolysaccharide on IL-1β and Nrf2 in Adult Rat Substantia Nigra Are Partly Normalized by a Spirulina-Enriched Diet.Neuroimmunomodulation · 2016Article
- Assessment of C-phycocyanin effect on astrocytes-mediated neuroprotection against oxidative brain injury using 2D and 3D astrocyte tissue model.Scientific reports · 2015Article
- NADPH Oxidase Activity in Cerebral Arterioles Is a Key Mediator of Cerebral Small Vessel Disease-Implications for Prevention.Healthcare (Basel, Switzerland) · 2015Review
- Behavioral and Histopathological Study of Changes in Spinal Cord Injured Rats Supplemented with Spirulina platensis.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- C-phycocyanin confers protection against oxalate-mediated oxidative stress and mitochondrial dysfunctions in MDCK cells.PloS one · 2014Article
- Neuroprotective Effects of a Butanol Fraction of Rosa hybrida Petals in a Middle Cerebral Artery Occlusion Model.Biomolecules & therapeutics · 2013Article
- Melatonin-based therapeutics for neuroprotection in stroke.International journal of molecular sciences · 2013Review
- Protective Effect of Water ExtractedPharmacognosy magazineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies indicate that the intake of Mediterranean-style diet is inversely associated with risk of stroke, cardiovascular diseases, and cancer. Spirulina is widely used nutritional supplement rich in proteins and antioxidants. Evidence demonstrates that the impaired energy metabolism and the excessive generation of reactive oxygen radicals contribute to the brain injury associated with cerebral ischemia. In the present study, the protective effect of Spirulina was investigated in transient middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia-reperfusion injury in rats. Male albino rats were divided into six groups: control, sham-operated group, ischemic control group, and Spirulina-pretreated groups (45, 90 and 180 mg/kg/p.o.). Spirulina was administered once a day, for 7 days. The rats were subjected to a 2-h right MCAO via the intraluminal filament technique and 22 h of reperfusion. Pretreatment with Spirulina significantly reduced the histological changes and neurological deficits. Spirulina at a dose of 180 mg/kg significantly reversed the elevated brain malondialdehyde (MDA) content and restored the decreased activities of brain superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) indicating that Spirulina has the protective potential against cerebral ischemia injury and its protective effects may be due to its antioxidant property.
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