ArticleParasitology research2010
Clinical, laboratory and pathological findings in dogs experimentally infected with Angiostrongylus vasorum.
Article in Parasitology research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 88 citations in OpenAlex.
- Monthly administrations of milbemycin oxime plus afoxolaner chewable tablets to prevent Angiostrongylus vasorum infection in dogs.Parasites & vectors · 2016Trial
- Canine angiostrongylosis in naturally infected dogs: clinical approach and monitoring of infection after treatment.TheScientificWorldJournal · 2013Trial
- Efficacy of a single oral administration of a formulation of fluralaner, moxidectin and pyrantel (BRAVECTO® TriUNO) in dogs for the treatment and prevention of angiostrongylosis.Parasites & vectors · 2026Article
- First report of Angiostrongylus vasorum parasitizing lesser grison (Galictis cuja) (Mustelidae) in Brazil.Veterinary research communications · 2026Article
- Haemocyte-Derived Innate Immune Reactions of the Giant African Snail (Animals : an open access journal from MDPI · 2026Article
- Increased metallopeptidase activity, compromised endothelial integrity and impaired pathogen recognition revealed by transcriptomics inCurrent research in parasitology & vector-borne diseases · 2026Article
- In vitro cytokine response of circulating mononuclear cells from healthy dogs to stage-specific antigens of Angiostrongylus vasorum.BMC veterinary research · 2025Article
- Establishment and validation of red fox (vulpes vulpes) airway epithelial cell cultures at the air-liquid-interface.Scientific reports · 2025Article
- Article
- Host-specific vascular endothelial cell responses toFrontiers in cellular and infection microbiology · 2025Article
- Organ Tropism ofPathogens (Basel, Switzerland) · 2024Article
- Is theFrontiers in veterinary science · 2023Article
- Nationwide Seroprevalence Survey ofMicroorganisms · 2022Article
- Review
- Hemostatic Dysfunction in Dogs Naturally Infected withPathogens (Basel, Switzerland) · 2022Review
- Fox Serum Proteomics Analysis Suggests Host-Specific Responses toPathogens (Basel, Switzerland) · 2021Article
- Highly Variable Clinical Pictures in Dogs Naturally Infected withPathogens (Basel, Switzerland) · 2021Article
- Coagulation Status in Dogs Naturally Infected withPathogens (Basel, Switzerland) · 2021Article
- CanineBiology · 2021Article
- Gross, microscopic, radiologic, echocardiographic and haematological findings in rats experimentally infected withParasitology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this comparative study was to investigate the development of clinical signs and accompanying haematological, coproscopic and pathological findings as a basis for the monitoring of health condition of Angiostrongylus vasorum infected dogs. Six beagles were orally inoculated with 50 (n=3) or 500 (n=3) A. vasorum third stage larvae (L3) obtained from experimentally infected Biomphalaria glabrata snails. Two dogs were treated with moxidectin/imidacloprid spot-on solution and two further dogs with an oral experimental compound 92 days post infection (dpi), and were necropsied 166 dpi. Two untreated control dogs were necropsied 97 dpi. Prepatency was 47-49 days. Dogs inoculated with 500 L3 exhibited earlier (from 42 dpi) and more severe respiratory signs. Clinical signs resolved 12 days after treatment and larval excretion stopped within 20 days in all four treated dogs. Upon necropsy, 10 and 170 adult worms were recovered from the untreated dogs inoculated with 50 and 500 L3, respectively. Adult worms were also found in two treated dogs, in the absence of L1 or eggs. Despite heavy A. vasorum infection load and severe pulmonary changes including vascular thrombosis, only mild haematological changes were observed. Eosinophilia was absent but the presence of plasma cells was observed. Neutrophilic leucocytes showed a transient increase but only after treatment. Signs for coagulopathies were slight; nevertheless coagulation parameters were inoculation dose dependent. Ten weeks after treatment pulmonary fibrosis was still present. Infections starting from 50 L3 of A. vasorum had a massive impact on lung tissues and therefore on the health of affected dogs, particularly after prepatency, although only mild haematological abnormalities were evident.
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Registered trials
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