Evidence map›Paper›PMID 20700603›Full record

ArticleLangenbeck's archives of surgery2010

Intraoperative laser fluorescence angiography in colorectal surgery: a noninvasive analysis to reduce the rate of anastomotic leakage.

Stefanie Kudszus, Christian Roesel, Alexander Schachtrupp, Jörg J Höer

2 registry-linked trialsAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Langenbeck's archives of surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 168 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 23 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04904081 phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

The Use of Indocyanine Green Angiography in Pediatric Colorectal Surgery: A Feasibility Randomized Controlled Trial

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2021 to 2024Enrolled12ConditionsHirschsprung Disease, Anorectal MalformationsArmsIndocyanine green
NCT07486570 narecruitingnot on this mapstarted 2026, after this paper: background citation

Anastomotic Leakage Prevention by Endovascular Stenting of the Superior Mesenteric Artery

TypeinterventionalSponsorMedisch Spectrum TwenteRan2026 to 2029Enrolled360ConditionsMesenteric Vascular Disease, Colorectal Surgery, Preventive InterventionArmsPercutaneous transluminal angiopasty and endovascular stenting of the superior mesenteric artery, Colon surgery, Mono antiplatelet therapy with Ascal 80mg daily
3 · Its place in the literature

Who cites it

168 citing papers in PubMed, 23 syntheses or guidelines pooled it.

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108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stefanie KudszusKaiserswerther Diakonie Düsseldorf, Düsseldorf, Germany.
Christian Roesel
Alexander Schachtrupp
Jörg J Höer

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeUp to 19% of all colorectal resections develop clinically apparent insufficiencies. Insufficient perfusion of the anastomosis is recognized as an important risk factor. As tissue perfusion can be objectified intraoperatively using laser fluorescence angiography (LFA), its effect on the rate of anastomotic complications was evaluated in a retrospective matched-pairs analysis.

methodsBetween 2003 and 2008, all anastomosis or resection margins in colorectal cancer resections were investigated intraoperatively using LFA (LFA group). Patients with colorectal cancer resections between 1998 and 2003 without LFA served as the control group. Four hundred two patients were matched for age, T-stage, type of resection and anastomosis, defunctioning stoma, administration of blood, emergency conditions, and body mass index. Statistical analysis was performed using the Fisher and the Wilcoxon tests.

resultsTwenty-two surgical revisions were necessary due to anastomotic leakage, seven (3.5%) in the LFA group and 15 (7.5%) in the control group. Subgroup analysis revealed that in elective resections the rate of revision was 3.1% (LFA group) and 7.7% (control group) (p = 0.04, risk of revision (ROR) reduced by 60%). In patients older than 70 years, the rate of revision was 4.3% (LFA group) compared to 11.9% (control group) (p = 0.04, ROR reduced by 64%). After hand-sewn anastomosis, the rate of revision was 1.2% (LFA group) and 8.5% (control group) (p = 0.03, ROR reduced by 84%). Hospital stay was significantly reduced in the LFA group (Wilcoxon test; p = 0.01).

conclusionThere was an overall reduction in the absolute revision rate of 4% in the LFA group and a significantly reduced rate of revision in the subgroup analysis of patients undergoing elective colorectal resections, in patients older than 70 years and in patients with hand-sewn anastomosis. This demonstrates that LFA is a method that may significantly reduce not only the rate of severe complications in colorectal surgery but also the hospital length of stay.

Indexed as

Intraoperative PeriodAgedAged, 80 and overAnastomotic LeakColectomyColonColorectal NeoplasmsFemaleFluorescein AngiographyHumansIleumIntraoperative ComplicationsLength of StayMaleMatched-Pair AnalysisMiddle Aged

Identifiers

PMID20700603

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.