ArticlePloS one2010
Gene expression in chicken reveals correlation with structural genomic features and conserved patterns of transcription in the terrestrial vertebrates.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
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- ZmSSRP1 facilitates the progression of RNA polymerase II and is essential for kernel development in maize.The Plant cell · 2025Article
- HRT Atlas v1.0 database: redefining human and mouse housekeeping genes and candidate reference transcripts by mining massive RNA-seq datasets.Nucleic acids research · 2021Article
- Role of Gene Length in Control of Human Gene Expression: Chromosome-Specific and Tissue-Specific Effects.International journal of genomics · 2021Article
- Concordant expression pattern across multiple immune tissues of commercial broilers in response to avian pathogenic3 Biotech · 2019Article
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- Evolutionary fate and implications of retrocopies in the African coelacanth genome.BMC genomics · 2015Article
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- A detailed description of an economical setup for electroporation of chick embryos in ovo.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- Histological evidence: housekeeping genes beta-actin and GAPDH are of limited value for normalization of gene expression.Development genes and evolution · 2012Article
- Regions of homozygosity in the porcine genome: consequence of demography and the recombination landscape.PLoS genetics · 2012Article
- Differential gene expression from genome-wide microarray analyses distinguishes Lohmann Selected Leghorn and Lohmann Brown layers.PloS one · 2012Article
- Origin of amphibian and avian chromosomes by fission, fusion, and retention of ancestral chromosomes.Genome research · 2011Article
- Systematic analysis of gene expression level with tissue-specificity, function and protein subcellular localization in human transcriptome.Molecular biology reports · 2011Article
- Regional regulation of transcription in the bovine genome.PloS one · 2011Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe chicken is an important agricultural and avian-model species. A survey of gene expression in a range of different tissues will provide a benchmark for understanding expression levels under normal physiological conditions in birds. With expression data for birds being very scant, this benchmark is of particular interest for comparative expression analysis among various terrestrial vertebrates. METHODOLOGY/PRINCIPAL
findingsWe carried out a gene expression survey in eight major chicken tissues using whole genome microarrays. A global picture of gene expression is presented for the eight tissues, and tissue specific as well as common gene expression were identified. A Gene Ontology (GO) term enrichment analysis showed that tissue-specific genes are enriched with GO terms reflecting the physiological functions of the specific tissue, and housekeeping genes are enriched with GO terms related to essential biological functions. Comparisons of structural genomic features between tissue-specific genes and housekeeping genes show that housekeeping genes are more compact. Specifically, coding sequence and particularly introns are shorter than genes that display more variation in expression between tissues, and in addition intergenic space was also shorter. Meanwhile, housekeeping genes are more likely to co-localize with other abundantly or highly expressed genes on the same chromosomal regions. Furthermore, comparisons of gene expression in a panel of five common tissues between birds, mammals and amphibians showed that the expression patterns across tissues are highly similar for orthologous genes compared to random gene pairs within each pair-wise comparison, indicating a high degree of functional conservation in gene expression among terrestrial vertebrates.
conclusionsThe housekeeping genes identified in this study have shorter gene length, shorter coding sequence length, shorter introns, and shorter intergenic regions, there seems to be selection pressure on economy in genes with a wide tissue distribution, i.e. these genes are more compact. A comparative analysis showed that the expression patterns of orthologous genes are conserved in the terrestrial vertebrates during evolution.
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