ArticlePloS one2010
Adiponectin deficiency promotes tumor growth in mice by reducing macrophage infiltration.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Double-sided niche regulation in skin stem cell and cancer: mechanisms and clinical applications.Molecular cancer · 2025Review
- Role of Leptin and Adiponectin in Carcinogenesis.Cancers · 2023Review
- Adiponectin Suppresses Metastasis of Nasopharyngeal Carcinoma through Blocking the Activation of NF-κB and STAT3 Signaling.International journal of molecular sciences · 2022Article
- The Role of Adiponectin in the Skin.Biomolecules & therapeutics · 2022Review
- Melanoma Progression under Obesity: Focus on Adipokines.Cancers · 2021Review
- The miR-23a∼27a∼24-2 microRNA Cluster Promotes Inflammatory Polarization of Macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- The Influence of Tumor Microenvironment on Immune Escape of Melanoma.International journal of molecular sciences · 2020Review
- Glitazone loaded fat enhances adiponectin production and inhibits breast cancer cell proliferation.Molecular biology reports · 2019Article
- Cross-Talk between Inflammatory Mediators and the Epithelial Mesenchymal Transition Process in the Development of Thyroid Carcinoma.International journal of molecular sciences · 2019Review
- Adiponectin inhibits migration and invasion by reversing epithelial‑mesenchymal transition in non‑small cell lung carcinoma.Oncology reports · 2018Article
- The prognostic value of serum and bronchoalveolar lavage levels of adiponectin in advanced non-small-cell lung cancer.Lung cancer management · 2017Article
- The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance.Oncotarget · 2017Review
- Heparanase is required for activation and function of macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A prospective study of plasma adiponectin and pancreatic cancer risk in five US cohorts.Journal of the National Cancer Institute · 2013Article
- The role of adiponectin in cancer: a review of current evidence.Endocrine reviews · 2012Review
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- Molecular mechanisms of cancer development in obesity.Nature reviews. Cancer · 2011Review
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Adiponectin is an adipocyte-derived plasma protein that has been implicated in regulating angiogenesis, but the role of adiponectin in regulating this process is still controversial. In this study, in order to determine whether adiponectin affects tumor growth and tumor induced vascularization, we implanted B16F10 melanoma and Lewis Lung Carcinoma cells subcutaneously into adiponectin knockout and wild-type control mice, and found that adiponectin deficiency markedly promoted the growth of both tumors. Immunohistochemical analyses indicated that adiponectin deficiency reduced macrophage recruitment to the tumor, but did not affect cancer cell mitosis, apoptosis, or tumor-associated angiogenesis. In addition, treatment with recombinant adiponectin did not affect the proliferation of cultured B16F10 tumor cells. Importantly, the restoration of microphage infiltration at an early stage of tumorigenesis by means of co-injection of B16F10 cells and macrophages reversed the increased tumor growth in adiponectin knockout mice. Thus, we conclude that the enhanced tumor growth observed in adiponectin deficient mice is likely due to the reduction of macrophage infiltration rather than enhanced angiogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.