ArticlePloS one2010
The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.BMJ (Clinical research ed.) · 2014Pooled it
- Differential Effect of Initiating Moderate Red Wine Consumption on 24-h Blood Pressure by Alcohol Dehydrogenase Genotypes: Randomized Trial in Type 2 Diabetes.American journal of hypertension · 2016Trial
- Alcohol Consumption and Acute Coronary Syndrome: Epidemiology, Pathophysiology, and Clinical Perspectives.Journal of clinical medicine · 2025Review
- Nutrigenetics and metabolic syndrome: evidence from a systematic review of the literature.Genes & nutrition · 2025Review
- Understanding the link between ALDH2 genotypes and diabetes.Frontiers in endocrinology · 2025Article
- Frequency and Sex-Specific Associations of Metabolic Syndrome in Rwandans Seeking Outpatient Care: A Cross Sectional, Single Centre Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by ALDH2 and ADH1B Polymorphisms in Japanese Men.Journal of epidemiology · 2018Article
- Genetic variants in ALDH1B1 and alcohol dependence risk in a British and Irish population: A bioinformatic and genetic study.PloS one · 2017Article
- Mendelian randomisation study of the associations of vitamin B12 and folate genetic risk scores with blood pressure and fasting serum lipid levels in three Danish population-based studies.European journal of clinical nutrition · 2016Article
- The Protective Effect of Low-Dose Ethanol on Myocardial Fibrosis through Downregulating the JNK Signaling Pathway in Diabetic Rats.Journal of diabetes research · 2016Article
- Associations between aldehyde dehydrogenase 2 (ALDH2) genetic polymorphisms, drinking status, and hypertension risk in Japanese adult male workers: a case-control study.Environmental health and preventive medicine · 2016Article
- The Relationship between Alcohol Consumption and Incidence of Glycometabolic Abnormality in Middle-Aged and Elderly Chinese Men.International journal of endocrinology · 2016Article
- Cardiovascular risks and benefits of moderate and heavy alcohol consumption.Nature reviews. Cardiology · 2015Review
- Article
- MTHFR C677T genotype and cardiovascular risk in a general population without mandatory folic acid fortification.European journal of nutrition · 2014Article
- Investigating the causal effect of vitamin D on serum adiponectin using a Mendelian randomization approach.European journal of clinical nutrition · 2014Article
- Synergistic association between two alcohol metabolism relevant genes and coronary artery disease among Chinese hypertensive patients.PloS one · 2014Article
- No association between loss-of-function mutations in filaggrin and diabetes, cardiovascular disease, and all-cause mortality.PloS one · 2013Article
- Association between Lifestyle Factors and Metabolic Syndrome among African Americans in the United States.Journal of nutrition and metabolism · 2013Article
- Proximal correlates of metabolic phenotypes during 'at-risk' and 'case' stages of the metabolic disease continuum.Nutrition & diabetes · 2012Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiological studies have shown a J- or U-shaped relation between alcohol and type 2 diabetes and coronary heart disease (CHD). The underlying mechanisms are not clear. The aim was to examine the association between alcohol intake and diabetes and intermediate CHD risk factors in relation to selected ADH and ALDH gene variants. METHODOLOGY/PRINCIPAL
findingsCross-sectional study including 6,405 Northern European men and women aged 30-60 years from the general population of Copenhagen, Denmark. Data were collected with self-administered questionnaires, a physical examination, a 2 hour oral glucose tolerance test, and various blood tests. J shaped associations were observed between alcohol and diabetes, metabolic syndrome (MS), systolic and diastolic blood pressure, triglyceride, total cholesterol, and total homocysteine. Positive associations were observed with insulin sensitivity and HDL cholesterol, and a negative association with insulin release. Only a few of the selected ADH and ALDH gene variants was observed to have an effect. The ADH1c (rs1693482) fast metabolizing CC genotype was associated with an increased risk of impaired glucose tolerance (IGT)/diabetes compared to the CT and TT genotypes. Significant interactions were observed between alcohol and ADH1b (rs1229984) with respect to LDL and between alcohol and ALDH2 (rs886205) with respect to IGT/diabetes. CONCLUSIONS/SIGNIFICANCE: The selected ADH and ALDH gene variants had only minor effects, and did not seem to markedly modify the health effects of alcohol drinking. The observed statistical significant associations would not be significant, if corrected for multiple testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.