ArticlePloS one2010
Attraction basins as gauges of robustness against boundary conditions in biological complex systems.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Boolean modelling in plant biology.Quantitative plant biology · 2022Review
- Entropy as a Robustness Marker in Genetic Regulatory Networks.Entropy (Basel, Switzerland) · 2020Article
- An Integrative Network Modeling Approach to T CD4 Cell Activation.Frontiers in physiology · 2020Article
- Biological Networks Entropies: Examples in Neural Memory Networks, Genetic Regulation Networks and Social Epidemic Networks.Entropy (Basel, Switzerland) · 2018Article
- A Network Model to Describe the Terminal Differentiation of B Cells.PLoS computational biology · 2016Article
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Authors and funding
5 authors.
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Abstract
One fundamental concept in the context of biological systems on which researches have flourished in the past decade is that of the apparent robustness of these systems, i.e., their ability to resist to perturbations or constraints induced by external or boundary elements such as electromagnetic fields acting on neural networks, micro-RNAs acting on genetic networks and even hormone flows acting both on neural and genetic networks. Recent studies have shown the importance of addressing the question of the environmental robustness of biological networks such as neural and genetic networks. In some cases, external regulatory elements can be given a relevant formal representation by assimilating them to or modeling them by boundary conditions. This article presents a generic mathematical approach to understand the influence of boundary elements on the dynamics of regulation networks, considering their attraction basins as gauges of their robustness. The application of this method on a real genetic regulation network will point out a mathematical explanation of a biological phenomenon which has only been observed experimentally until now, namely the necessity of the presence of gibberellin for the flower of the plant Arabidopsis thaliana to develop normally.
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