Evidence map›Paper›PMID 20700472›Full record

ArticleMolecular & cellular biomechanics : MCB2010

Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function.

Gang Bao, Roger D Kamm, Wendy Thomas, Wonmuk Hwang, Daniel A Fletcher, Alan J Grodzinsky, Cheng Zhu, Mohammad R K Mofrad

Abstract read
In one paragraph

Article in Molecular & cellular biomechanics : MCB, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Morphogenesis can be driven by properly parametrised mechanical feedback.The European physical journal. E, Soft matter · 2013
    Article
  11. The interaction of vinculin with actin.PLoS computational biology · 2013
    Article
  12. Shp2 plays a crucial role in cell structural orientation and force polarity in response to matrix rigidity.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gang BaoDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.
Roger D Kamm
Wendy Thomas
Wonmuk Hwang
Daniel A Fletcher
Alan J Grodzinsky
Cheng Zhu
Mohammad R K Mofrad

Funding

Nanotechnology: Detection &Analysis of Plaque FormationU01HL080711 · NHLBI · EMORY UNIVERSITY · PI BAO, GANG · 2005 to 2009
$11.0M
Visualizing Single Integrin Conformational Changes on Living CellsR01AI044902 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2000 to 2016
$5.8M
Ligand Binding Kinetics and Cell Adhesion by Fc ReceptorR01AI038282 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2001 to 2005
$1.9M
ELECTROMECHANICS OF CARTILAGE: SYNTHESIS &DEGRADATIIONR01AR033236 · NIAMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRODZINSKY, ALAN J. · 1986 to 2010
$1.5M
CARTILAGE METABOLIC RESPOSE TO LOADING: TARGET MOLECULESR37AR033236 · NIAMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRODZINSKY, ALAN J · 1995 to 2004
$1.2M
Computational and single molecule analysis of kinesin's atomistic machineryR01GM087677 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI HWANG, WONMUK, LANG, MATTHEW J. · 2009 to 2012
$911k
MSM-Multi-scale Analysis of Cellular Force Transmission and Biochemical ActivatioR01GM076689 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KAMM, ROGER D. · 2005 to 2007
$871k
Kinetic analysis of ligand binding by TCR and CD8R56AI038282 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2012 to 2012
$389k
KINETIC PROPERTIES OF SELECTINSR21AI044902 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2000 to 2000
$71k
LIGAND BONDING FORCE AND CELL ADHESION BY CD16 ISOFORMSR29AI038282 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 1995 to 1999
–
NHLBI NIH HHS U01 HL080711NIAID NIH HHS R01 AI038282NIAID NIH HHS R01 AI044902NIAMS NIH HHS R01 AR033236NIGMS NIH HHS R01 GM076689NIGMS NIH HHS R01 GM087677
6 · The paper itself

Abstract

Recent advances have led to the emergence of molecular biomechanics as an essential element of modern biology. These efforts focus on theoretical and experimental studies of the mechanics of proteins and nucleic acids, and the understanding of the molecular mechanisms of stress transmission, mechanosensing and mechanotransduction in living cells. In particular, single-molecule biomechanics studies of proteins and DNA, and mechanochemical coupling in biomolecular motors have demonstrated the critical importance of molecular mechanics as a new frontier in bioengineering and life sciences. To stimulate a more systematic study of the basic issues in molecular biomechanics, and attract a broader range of researchers to enter this emerging field, here we discuss its significance and relevance, describe the important issues to be addressed and the most critical questions to be answered, summarize both experimental and theoretical/computational challenges, and identify some short-term and long-term goals for the field. The needs to train young researchers in molecular biomechanics with a broader knowledge base, and to bridge and integrate molecular, subcellular and cellular level studies of biomechanics are articulated.

Identifiers

PMID20700472
PMCPMC2917781

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.