ArticlePLoS genetics2010
The extinction dynamics of bacterial pseudogenes.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 187 citations in OpenAlex.
- DNA repair pathways in Mycobacterium leprae: insights from reductive genome evolution and therapeutic opportunities.Archives of microbiology · 2026Review
- Annotating the pangenome reveals the diversity in the genetic basis for metabolic enzymes.Science advances · 2026Article
- The transcriptional and translational outcomes for pseudogenes in bacterial endosymbionts.Molecular biology and evolution · 2026Article
- Depth-associated selection and drift shape persistent microbial populations in Holocene lake sediments.mSystems · 2026Article
- Prophage genomics of carbapenemase-producing Klebsiella pneumoniae from animal-derived food sources.Scientific reports · 2026Article
- The pangenome: a statistical model, not a fixed biological property.Bioinformatics advances · 2026Review
- Genome Architecture and Speciation in Plants and Animals.Molecular ecology · 2025Review
- Unravelling the genomic landscape of Acinetobacter baumannii: deep dive into virulence factors, resistance elements, and evolutionary adaptations.Molecular genetics and genomics : MGG · 2025Article
- Pseudogenes and host specialization in the emergent bacterial plant pathogenApplied and environmental microbiology · 2025Article
- Pseudogenes in plasmid genomes reveal past transitions in plasmid mobility.Nucleic acids research · 2024Article
- Genome streamlining in Parcubacteria transitioning from soil to groundwater.Environmental microbiome · 2024Article
- Loss to gain: pseudogenes in microorganisms, focusing on eubacteria, and their biological significance.Applied microbiology and biotechnology · 2024Review
- Comprehensive virulence profiling and evolutionary analysis of specificity determinants inmSystems · 2024Article
- Many purported pseudogenes in bacterial genomes are bona fide genes.BMC genomics · 2024Article
- Multi-Omics integration can be used to rescue metabolic information for some of the dark region of the Pseudomonas putida proteome.BMC genomics · 2024Article
- Pseudogenes act as a neutral reference for detecting selection in prokaryotic pangenomes.Nature ecology & evolution · 2024Article
- The Constructive Black Queen hypothesis: new functions can evolve under conditions favouring gene loss.The ISME journal · 2024Article
- MAGs-centric crack: how long will, spore-positiveFrontiers in microbiology · 2024Article
- A large-scale phylogeny-guided analysis of pseudogenes inMicrobiology spectrum · 2023Article
- Prokaryotic Pangenomes Act as Evolving Ecosystems.Molecular biology and evolution · 2023Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Pseudogenes are usually considered to be completely neutral sequences whose evolution is shaped by random mutations and chance events. It is possible, however, for disrupted genes to generate products that are deleterious due either to the energetic costs of their transcription and translation or to the formation of toxic proteins. We found that after their initial formation, the youngest pseudogenes in Salmonella genomes have a very high likelihood of being removed by deletional processes and are eliminated too rapidly to be governed by a strictly neutral model of stochastic loss. Those few highly degraded pseudogenes that have persisted in Salmonella genomes correspond to genes with low expression levels and low connectivity in gene networks, such that their inactivation and any initial deleterious effects associated with their inactivation are buffered. Although pseudogenes have long been considered the paradigm of neutral evolution, the distribution of pseudogenes among Salmonella strains indicates that removal of many of these apparently functionless regions is attributable to positive selection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.