ArticleEuropean journal of clinical nutrition2010
Vitamin D status and measures of cognitive function in healthy older European adults.
Article in European journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 56 citations in OpenAlex.
- Role of Neural Stem Cells and Vitamin D Receptor (VDR)-Mediated Cellular Signaling in the Mitigation of Neurological Diseases.Molecular neurobiology · 2022Review
- Cognitive Status and Nutritional Markers in a Sample of Institutionalized Elderly People.Frontiers in aging neuroscience · 2022Article
- Serum vitamin D and cognition in a cohort of Boston-area Puerto Ricans.Nutritional neuroscience · 2020Article
- Is calcifediol better than cholecalciferol for vitamin D supplementation?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Review
- Vitamin D Status and Intakes and Their Association With Cognitive Trajectory in a Longitudinal Study of Urban Adults.The Journal of clinical endocrinology and metabolism · 2018Article
- Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis.The Journal of physiology · 2017Review
- Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study.European journal of nutrition · 2017Article
- Serum 25-hydroxyvitamin D is associated with reduced verbal episodic memory in healthy, middle-aged and older adults.European journal of nutrition · 2016Article
- Vitamin D, Cognition and Alzheimer's Disease: The Therapeutic Benefit is in the D-Tails.Journal of Alzheimer's disease : JAD · 2016Review
- Serum 25-hydroxyvitamin D and cognitive decline in the very old: the Newcastle 85+ Study.European journal of neurology · 2015Article
- Beneficial effects of vitamin D on falls and fractures: is cognition rather than bone or muscle behind these benefits?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Review
- Plasma vitamin D levels and cognitive function in aging women: the nurses' health study.The journal of nutrition, health & aging · 2014Article
- Sex differences in cognition in healthy elderly individuals.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2012Article
- Association between serum 25(OH) vitamin D and the risk of cognitive decline in older women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- Vitamin D and Brain Imaging in the Elderly: Should we Expect Some Lesions Specifically Related to Hypovitaminosis D?The open neuroimaging journal · 2012Article
- The role of vitamers and dietary-based metabolites of vitamin D in prevention of vitamin D deficiency.Food & nutrition research · 2012Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesData from human studies that have investigated the association between vitamin D status and cognitive function in elderly adults are conflicting. The objective of this study was to assess vitamin D status (reflected by serum 25-hydroxyvitamin D (25(OH)D)) in older European subjects (n=387; aged 55-87 years) and examine its association with measures of cognitive function. SUBJECTS/
methodsSerum 25(OH)D was assessed using enzyme-linked immunosorbent assay, whereas measures of cognitive function were assessed using a comprehensive Cambridge Neuropsychological Testing Automated Battery (CANTAB).
resultsIn all, 12, 36 and 64% of subjects had serum 25(OH)D concentrations <30, <50 and <80 nmol/l, respectively, throughout the year. Serum 25(OH)D was significantly and inversely correlated with four assessments within the spatial working memory (SWM) test parameter (SWM between errors (r=-0.166; P=0.003); SWM between errors 8 boxes (r=-0.134; P=0.038); SWM strategy (r=-0.246; P<0.0001); and SWM total errors (r=-0.174; P<0.003)). When subjects were stratified on the basis of tertiles (T) of serum 25(OH)D (<47.6 (T(1)); 47.6-85.8 (T(2)); and >85.8 (T(3)) nmol/l), fewer errors in SWM test scores occurred in subjects in the third T when compared with the first T (P<0.05-0.084). Stratification by sex showed that these differences between tertiles strengthened (P<0.001-0.043) in the females, but the differences were not significant (P>0.6) in males.
conclusionsVitamin D insufficiency, but not deficiency, is widespread in the older population of several European countries. Low vitamin D status was associated with a reduced capacity for SWM, particularly in women.
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