ArticleThe Plant cell2010
Network analysis of enzyme activities and metabolite levels and their relationship to biomass in a large panel of Arabidopsis accessions.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
72 citing papers in PubMed.
- Integrated analysis of metabolites and enzyme activities reveals the plasticity of central carbon metabolism in grape (Horticulture research · 2025Article
- Sink strength, nutrient allocation, cannabinoid yield, and associated transcript profiles vary in two drug-type Cannabis chemovars.Journal of experimental botany · 2025Article
- A rapid method to quantify vein density in CPlant, cell & environment · 2023Article
- The Metabolic Profile of Young, Watered Chickpea Plants Can Be Used as a Biomarker to Predict Seed Number under Terminal Drought.Plants (Basel, Switzerland) · 2023Article
- Wheat Oxylipins in Response to Aphids, COMolecules (Basel, Switzerland) · 2023Article
- Natural variation of respiration-related traits in plants.Plant physiology · 2023Review
- Sugar loading is not required for phloem sap flow in maize plants.Nature plants · 2022Article
- The metabolomic landscape of rice heterosis highlights pathway biomarkers for predicting complex phenotypes.Plant physiology · 2021Article
- Guidelines for correlation coefficient threshold settings in metabolite correlation networks exemplified on a potato association panel.BMC bioinformatics · 2021Article
- Jasmonic Acid Signaling Pathway in Response to Abiotic Stresses in Plants.International journal of molecular sciences · 2020Review
- Biomarkers for grain yield stability in rice under drought stress.Journal of experimental botany · 2020Article
- Simple semi-high throughput determination of activity signatures of key antioxidant enzymes for physiological phenotyping.Plant methods · 2020Article
- A genome-wide scan shows evidence for local adaptation in a widespread keystone Neotropical forest tree.Heredity · 2019Article
- Article
- Contrasting nutrient-disease relationships: Potassium gradients in barley leaves have opposite effects on two fungal pathogens with different sensitivities to jasmonic acid.Plant, cell & environment · 2018Article
- Genome assembly of the Pink Ipê (Handroanthus impetiginosus, Bignoniaceae), a highly valued, ecologically keystone Neotropical timber forest tree.GigaScience · 2018Article
- Genome-Wide Association Mapping Reveals That Specific and Pleiotropic Regulatory Mechanisms Fine-Tune Central Metabolism and Growth in Arabidopsis.The Plant cell · 2017Article
- Predicting future biomass yield inGlobal change biology. Bioenergy · 2017Article
- Spatially resolved metabolic analysis reveals a central role for transcriptional control in carbon allocation to wood.Journal of experimental botany · 2017Article
- Genetic dissection of metabolite variation in Arabidopsis seeds: evidence for mQTL hotspots and a master regulatory locus of seed metabolism.Journal of experimental botany · 2017Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural genetic diversity provides a powerful resource to investigate how networks respond to multiple simultaneous changes. In this work, we profile maximum catalytic activities of 37 enzymes from central metabolism and generate a matrix to investigate species-wide connectivity between metabolites, enzymes, and biomass. Most enzyme activities change in a highly coordinated manner, especially those in the Calvin-Benson cycle. Metabolites show coordinated changes in defined sectors of metabolism. Little connectivity was observed between maximum enzyme activities and metabolites, even after applying multivariate analysis methods. Measurements of posttranscriptional regulation will be required to relate these two functional levels. Individual enzyme activities correlate only weakly with biomass. However, when they are used to estimate protein abundances, and the latter are summed and expressed as a fraction of total protein, a significant positive correlation to biomass is observed. The correlation is additive to that obtained between starch and biomass. Thus, biomass is predicted by two independent integrative metabolic biomarkers: preferential investment in photosynthetic machinery and optimization of carbon use.
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