ArticleCerebral cortex (New York, N.Y. : 1991)2011
VIP, CRF, and PACAP act at distinct receptors to elicit different cAMP/PKA dynamics in the neocortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
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- Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025Review
- Emerging pharmacological targets for alcohol use disorder.Alcohol (Fayetteville, N.Y.) · 2024Review
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- Functional and morphological adaptation of medial prefrontal corticotropin releasing factor receptor 1-expressing neurons in male mice following chronic ethanol exposure.Neurobiology of stress · 2024Article
- Vasoactive intestinal peptide excites GnRH neurons via KCa3.1, a potential player in the slow afterhyperpolarization current.Frontiers in cellular neuroscience · 2024Article
- Pituitary Adenylate Cyclase-Activating Polypeptide in Learning and Memory.Frontiers in cellular neuroscience · 2021Review
- Combined Optogenetic Approaches Reveal Quantitative Dynamics of Endogenous Noradrenergic Transmission in the Brain.iScience · 2020Article
- Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp.Journal of visualized experiments : JoVE · 2018Article
- Supragranular Pyramidal Cells Exhibit Early Metabolic Alterations in the 3xTg-AD Mouse Model of Alzheimer's Disease.Frontiers in cellular neuroscience · 2018Article
- Distribution, physiology and pharmacology of relaxin-3/RXFP3 systems in brain.British journal of pharmacology · 2017Review
- High-resolution characterization of a PACAP-EGFP transgenic mouse model for mapping PACAP-expressing neurons.The Journal of comparative neurology · 2016Article
- Molecular correlates of cortical network modulation by long-term sensory experience in the adult rat barrel cortex.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Vasoactive intestinal polypeptide mediates circadian rhythms in mammalian olfactory bulb and olfaction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Single-fluorophore biosensors based on conformation-sensitive GFP variants.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Revisiting enigmatic cortical calretinin-expressing interneurons.Frontiers in neuroanatomy · 2014Review
- cAMP signaling microdomains and their observation by optical methods.Frontiers in cellular neuroscience · 2014Review
- Noradrenalin and dopamine receptors both control cAMP-PKA signaling throughout the cerebral cortex.Frontiers in cellular neuroscience · 2014Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The functional significance of diverse neuropeptide coexpression and convergence onto common second messenger pathways remains unclear. To address this question, we characterized responses to corticotropin-releasing factor (CRF), pituitary adenylate cyclase-activating peptide (PACAP), and vasoactive intestinal peptide (VIP) in rat neocortical slices using optical recordings of cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) sensors, patch-clamp, and single-cell reverse transcription-polymerase chain reaction. Responses of pyramidal neurons to the 3 neuropeptides markedly differed in time-course and amplitude. Effects of these neuropeptides on the PKA-sensitive slow afterhyperpolarization current were consistent with those observed with cAMP/PKA sensors. CRF-1 receptors, primarily expressed in pyramidal cells, reportedly mediate the neocortical effects of CRF. PACAP and VIP activated distinct PAC1 and VPAC1 receptors, respectively. Indeed, a selective VPAC1 antagonist prevented VIP responses but had a minor effect on PACAP responses, which were mimicked by a specific PAC1 agonist. While PAC1 and VPAC1 were coexpressed in pyramidal cells, PAC1 expression was also frequently detected in interneurons, suggesting that PACAP has widespread effects on the neuronal network. Our results suggest that VIP and CRF, originating from interneurons, and PACAP, expressed mainly by pyramidal cells, finely tune the excitability and gene expression in the neocortical network via distinct cAMP/PKA-mediated effects.
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