ReviewClinics in geriatric medicine2010
Age-related changes in the musculoskeletal system and the development of osteoarthritis.
Review in Clinics in geriatric medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02798900 (The Effect of a Functional Task-training Program Combined With Therapeutic Ultrasound on Pain, Strength, Gait Biomechanics and Functionality in Adults With Hip Osteoarthritis), which is not on this map. Cited by 202 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of a Functional Task-training Program Combined With Therapeutic Ultrasound on Pain, Strength, Gait Biomechanics and Functionality in Adults With Hip Osteoarthritis
Who cites it
202 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Noninvasive electrical stimulation on pain and function in knee osteoarthritis in middle-aged and older adults: systematic review and meta-analysis of randomized clinical trials.Frontiers in medicine · 2026Pooled it
- The Effects of High-Intensity Interval Training on Basketball Players: A Systematic Review and Meta-Analysis.Journal of sports science & medicine · 2025Pooled it
- Prevalence and incidence of osteoarthritis among people living in the Gulf Cooperation Council countries: a systematic review and meta-analysis.Clinical rheumatology · 2021Pooled it
- Association between aspartic acid repeat polymorphism of the asporin gene and risk of knee osteoarthritis: A systematic review and meta-analysis.Acta orthopaedica et traumatologica turcica · 2017Pooled it
- A Randomized Placebo-Controlled Dose-Response Trial of MuvzDrug design, development and therapy · 2025Trial
- Clinical Effect of Bushen Huoxue Method Combined with Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis and Its Effect on IL-1, IL-6, VEGF, and PGE-2.Journal of healthcare engineering · 2022Trial
- Trial
- Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint.Molecular and cellular biochemistry · 2017Trial
- Managing knee osteoarthritis with yoga or aerobic/strengthening exercise programs in older adults: a pilot randomized controlled trial.Rheumatology international · 2017Trial
- Kaatsu training to enhance physical function of older adults with knee osteoarthritis: Design of a randomized controlled trial.Contemporary clinical trials · 2015Trial
- Variations in the TNFα gene and their interactions with the IL4R and IL10 genes in relation to hand osteoarthritis.BMC musculoskeletal disorders · 2014Trial
- Investigation into the Short-Term Effects of Intra-Articular Allogenic PRP in the Equine LPS Model of Joint Inflammation: A Randomised Control Trial.Animals : an open access journal from MDPI · 2026Article
- Early rehabilitation after total hip or knee joint replacement: a narrative review.European journal of translational myology · 2026Article
- [Disease burden trends of site-specific osteoarthritis in China from 1990 to 2023 and the attribution to high body mass index].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Three-Month Administration of PB125 Modifies Histopathology, Redox Homeostasis, and Mobility in the Hartley Guinea Pig Model of Primary Osteoarthritis.Antioxidants (Basel, Switzerland) · 2026Article
- Cartilage degradation is followed by PAC1 receptor reduction in articular cartilage of human knee joints.GeroScience · 2026Article
- Bi-directional associations between alcohol consumption and pain among non-manual workers: a random-intercept cross-lagged panel analysis in the British Whitehall II cohort study.Alcohol and alcoholism (Oxford, Oxfordshire) · 2026Article
- Earliest evidence for intentional cremation of human remains in Africa.Science advances · 2026Article
- Article
- Hip Osteoarthritis and the Human Microbiome: Current Concepts, Biological Insights and Future Directions.Orthopedic reviews · 2026Article
142 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Osteoarthritis (OA) is the most common cause of chronic disability in older adults. Although classically considered a "wear and tear" degenerative condition of articular joints, recent studies have demonstrated an inflammatory component to OA that includes increased activity of several cytokines and chemokines in joint tissues that drive production of matrix-degrading enzymes. Rather than directly causing OA, aging changes in the musculoskeletal system contribute to the development of OA by making the joint more susceptible to the effects of other OA risk factors that include abnormal biomechanics, joint injury, genetics, and obesity. Age-related sarcopenia and increased bone turnover may also contribute to the development of OA. Understanding the basic mechanisms by which aging affects joint tissues should provide new targets for slowing or preventing the development of OA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.