ArticleBMC plant biology2010
The characterisation of AOP2: a gene associated with the biosynthesis of aliphatic alkenyl glucosinolates in Arabidopsis thaliana.
Article in BMC plant biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 60 citations in OpenAlex.
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- QTL and candidate gene analysis unveil genetic control of floret aliphatic glucosinolate side-chain modification inHorticulture research · 2025Article
- Glucosinolates can act as signals to modulate intercellular trafficking via plasmodesmata.The New phytologist · 2025Article
- Progresses and Prospects on Glucosinolate Detection in Cruciferous Plants.Foods (Basel, Switzerland) · 2024Review
- Identification andFrontiers in plant science · 2023Article
- Biosynthesis of anticancer phytochemical compounds and their chemistry.Frontiers in pharmacology · 2023Review
- Transcriptome analysis of melatonin regulating the transformation of glucoraphanin to sulforaphane in broccoli hairy roots.Physiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- Revisiting a GWAS peak in Arabidopsis thaliana reveals possible confounding by genetic heterogeneity.Heredity · 2021Article
- Influence of Genotype on High Glucosinolate Synthesis Lines ofInternational journal of molecular sciences · 2021Article
- Sustainable Use of Bioactive Compounds fromMolecules (Basel, Switzerland) · 2021Review
- Challenges and Opportunities of Light-Emitting Diode (LED) as Key to Modulate Antioxidant Compounds in Plants. A Review.Antioxidants (Basel, Switzerland) · 2020Review
- Effect of Photoperiod on Chinese Kale (Frontiers in plant science · 2020Article
- Overexpression of the MYB29 transcription factor affects aliphatic glucosinolate synthesis in Brassica oleracea.Plant molecular biology · 2019Article
- Comparative transcriptome analysis reveals defense responses against soft rot in Chinese cabbage.Horticulture research · 2019Article
- Biotechnological approaches in glucosinolate production.Journal of integrative plant biology · 2018Review
- A naturally occurring variation in theHorticulture research · 2018Article
- Enriching Glucoraphanin inFrontiers in plant science · 2017Article
- Biofortification of oilseed Brassica juncea with the anti-cancer compound glucoraphanin by suppressing GSL-ALK gene family.Scientific reports · 2015Article
- Three genes encoding AOP2, a protein involved in aliphatic glucosinolate biosynthesis, are differentially expressed in Brassica rapa.Journal of experimental botany · 2015Article
- Natural genetic variation in Arabidopsis thaliana defense metabolism genes modulates field fitness.eLife · 2015Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundGlucosinolates, a group of nitrogen and sulfur containing compounds associated with plant-insect interactions, are produced by a number of important Brassicaceae crop species. In Arabidopsis the AOP2 gene plays a role in the secondary modification of aliphatic (methionine-derived) glucosinolates, namely the conversion of methylsulfinylalkyl glucosinolates to form alkenyl glucosinolates, and also influences aliphatic glucosinolate accumulation.
resultsThis study characterises the primary structural variation in the coding sequences of the AOP2 gene and identifies three different AOP2 alleles based on polymorphisms in exon two. To help determine the regulatory mechanisms mediating AOP2 expression amongst accessions, AOP2 5' regulatory regions were also examined however no major differences were identified. Expression of the AOP2 gene was found to be most abundant in leaf and stem tissue and was also found to be light dependent, with a number of light regulatory elements identified in the promoter region of the gene. In addition, a study was undertaken to demonstrate that the Arabidopsis AOP2 gene product is functional in planta. The over-expression of a functional AOP2 allele was found to successfully convert the precursor methylsulfinyl alkyl glucosinolate into the alkenyl form.
conclusionsThe expression of the AOP2 gene has been found to be influenced by light and is most highly expressed in the photosynthetic parts of the Arabidopsis plant. The level of AOP2 transcript decreases rapidly in the absence of light. AOP2 exists as at least three alleles in different Arabidopsis accessions and we have demonstrated that one of these, AOP2-2, is functionally able to convert methylsulfinyl glucosinolates into the alkenyl form. The demonstration of the in planta functionality of the Arabisopsis AOP2 gene is an important step in determining the feasibility of engineering glucosinolate profiles in food plants.
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