ArticleBMC medical genetics2010
Asthma-susceptibility variants identified using probands in case-control and family-based analyses.
Article in BMC medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00021840 (Genetic Epidemiology of Asthma in Costa Rica), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Asthma in Costa Rica
Who cites it
11 citing papers in PubMed.
- Single-cell RNA sequencing reveals immunological link between house dust mite allergy and childhood asthma.Scientific reports · 2025Article
- Genetics and Epigenetics in Asthma.International journal of molecular sciences · 2021Review
- Pharmacometabolomics of Bronchodilator Response in Asthma and the Role of Age-Metabolite Interactions.Metabolites · 2019Article
- Reconstructing recent population history while mapping rare variants using haplotypes.Scientific reports · 2019Article
- Lessons Learned From GWAS of Asthma.Allergy, asthma & immunology research · 2019Review
- Novel eosinophilic gene expression networks associated with IgE in two distinct asthma populations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
- Insights Into Nicotinic Receptor Signaling in Nicotine Addiction: Implications for Prevention and Treatment.Current neuropharmacology · 2018Review
- Lessons from ten years of genome-wide association studies of asthma.Clinical & translational immunology · 2017Review
- A signal peptide missense mutation associated with nicotine dependence alters α2*-nicotinic acetylcholine receptor function.Neuropharmacology · 2014Article
- The state of genome-wide association studies in pulmonary disease: a new perspective.American journal of respiratory and critical care medicine · 2011Review
- Association of SERPINE2 with asthma.Chest · 2011Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundAsthma is a chronic respiratory disease whose genetic basis has been explored for over two decades, most recently via genome-wide association studies. We sought to find asthma-susceptibility variants by using probands from a single population in both family-based and case-control association designs.
methodsWe used probands from the Childhood Asthma Management Program (CAMP) in two primary genome-wide association study designs: (1) probands were combined with publicly available population controls in a case-control design, and (2) probands and their parents were used in a family-based design. We followed a two-stage replication process utilizing three independent populations to validate our primary findings.
resultsWe found that single nucleotide polymorphisms with similar case-control and family-based association results were more likely to replicate in the independent populations, than those with the smallest p-values in either the case-control or family-based design alone. The single nucleotide polymorphism that showed the strongest evidence for association to asthma was rs17572584, which replicated in 2/3 independent populations with an overall p-value among replication populations of 3.5E-05. This variant is near a gene that encodes an enzyme that has been implicated to act coordinately with modulators of Th2 cell differentiation and is expressed in human lung.
conclusionsOur results suggest that using probands from family-based studies in case-control designs, and combining results of both family-based and case-control approaches, may be a way to augment our ability to find SNPs associated with asthma and other complex diseases.
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