Trial reportAlcoholism, clinical and experimental research2010
A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study.
Trial report in Alcoholism, clinical and experimental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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Who cites it
40 citing papers in PubMed, 62 citations in OpenAlex.
- Dutasteride reduces alcohol's sedative effects in men in a human laboratory setting and reduces drinking in the natural environment.Psychopharmacology · 2014Trial
- Ventral frontal satiation-mediated responses to food aromas in obese and normal-weight women.The American journal of clinical nutrition · 2014Trial
- Voluntary intravenous self-administration of alcohol detects an interaction between GABAergic manipulation and GABRG1 polymorphism genotype: a pilot study.Alcoholism, clinical and experimental research · 2013Trial
- fMRI of the brain's response to stimuli experimentally paired with alcohol intoxication.Psychopharmacology · 2012Trial
- Association Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample.Risk management and healthcare policy · 2025Article
- Alcohol craving in the natural environment: Moderating roles of cue exposure, drinking, and alcohol sensitivity.Experimental and clinical psychopharmacology · 2023Article
- A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus.Nature protocols · 2022Article
- To Infuse or Ingest in Human Laboratory Alcohol Research.Alcoholism, clinical and experimental research · 2020Review
- Evidence for incentive salience sensitization as a pathway to alcohol use disorder.Neuroscience and biobehavioral reviews · 2019Review
- Sex differences in incentive motivation and the relationship to the development and maintenance of alcohol use disorders.Physiology & behavior · 2019Review
- Alcohol affects the P3 component of an adaptive stop signal task ERP.Alcohol (Fayetteville, N.Y.) · 2018Article
- A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity.Alcoholism, clinical and experimental research · 2018Review
- The neural correlates of alcohol-related aggression.Cognitive, affective & behavioral neuroscience · 2018Article
- Pathways to Youth Behavior: The Role of Genetic, Neural, and Behavioral Markers.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2018Article
- GABRA2, alcohol, and illicit drug use: An event-level model of genetic risk for polysubstance use.Journal of abnormal psychology · 2018Article
- Naltrexone ameliorates functional network abnormalities in alcohol-dependent individuals.Addiction biology · 2018Article
- Network analysis of the genomic basis of the placebo effect.JCI insight · 2017Article
- A pedigree-based proxy measure of genetic predisposition of drinking and alcohol use among female sex workers in China: a cross-sectional study.AIDS care · 2017Article
- Externalizing personality traits, empathy, and gray matter volume in healthy young drinkers.Psychiatry research. Neuroimaging · 2016Article
- Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?Frontiers in cellular neuroscience · 2016Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSignificant evidence has accumulated to suggest an association between single-nucleotide polymorphisms (SNPs) in the GABRA2 gene and alcoholism. However, research has yet to show an association between these polymorphisms and the human brain's reward system function. In this study, we stratified subjects who had participated in an fMRI study of alcohol cue responses according to their genotype at a SNP in GABRA2 (rs279871) shown to be associated with alcohol dependence (Edenberg et al., 2004).
methodsGenotyping showed 13 subjects to be homozygous for the high-risk allele (AA), and 23 subjects to be heterozygous (AG). In fMRI, subjects were exposed to the aromas of their preferred alcoholic drink odors (AO), as well as to appetitive control odors (ApCO) under both alcohol intoxication and placebo control conditions.
resultsHomozygous AA subjects had a larger [AO > ApCO] response than did AG subjects in medial frontal cortical areas thought to code reward value. However, AG subjects had a larger [AO > ApCO] effect in the ventral tegmental area. Alcohol intoxication did not alter these group differences.
conclusionsThese are the first data to suggest that GABRA2 genotype could affect the brain's responses to cues associated with alcohol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.