ReviewWorld journal of gastroenterology2010
Gastroesophageal reflux disease: From pathophysiology to treatment.
Review in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04105894 (Does Gastric Reflux Induce Sinonasal Symptoms?), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Does Gastric Reflux Induce Sinonasal Symptoms?
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Association between body mass index at different levels and risk of gastroesophageal reflux disease: a systematic review with dose-response meta-analysis.Frontiers in physiology · 2025Pooled it
- Gastric dysrhythmia in gastroesophageal reflux disease: a systematic review and meta-analysis.Esophagus : official journal of the Japan Esophageal Society · 2021Pooled it
- Proton pump inhibitors for chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2020Pooled it
- External validity of task-specific metrics for performance assessment in laparoscopic crural repair.Surgical endoscopy · 2026Article
- Esophageal motility disorders after COVID-19 infection.Scientific reports · 2025Observational
- Review
- Eversion cruroplasty and collar overwrap: a novel hybrid approach for refractory gastroesophageal reflux disease in children, with assessment of mid-term outcomes.Surgical endoscopy · 2025Article
- Assessment of upper respiratory and gut bacterial microbiomes during COVID-19 infection in adults: potential aerodigestive transmission.Scientific reports · 2025Article
- Effectiveness of Abdominal Breathing Exercise to Control Gastroesophageal Reflux Disease, a Randomized Controlled Trial.Journal of community hospital internal medicine perspectives · 2025Article
- pHoenix score: development and validation of a novel approach to decrease the number of inconclusive GERD diagnoses.Surgical endoscopy · 2024Observational
- Polypharmacy and pattern of medication use among patients with gastroesophageal reflux disease: results from Pars Cohort study.BMC gastroenterology · 2023Article
- A prospective study of extraesophageal reflux and potential microaspiration in patients hospitalized with COVID-19 in Jordan.BMC pulmonary medicine · 2023Article
- Immune system and microbiome in the esophagus: implications for understanding inflammatory diseases.The FEBS journal · 2022Review
- One-Anastomosis and Roux-en-Y Gastric Bypass Promote Similar Weight Loss, Patient Satisfaction, Quality of Life, Inflammation Grade, and Cellular Damage in the Esophagus and Gastric Pouch in a Short-term Follow-up.Journal of obesity & metabolic syndrome · 2021Article
- Collaboration between GI surgery & Gastroenterology improves understanding of the optimal antireflux valve-the omega flap valve.Surgical endoscopy · 2021Article
- Can Omentopexy Reduce the Incidence of Gastroesophageal Reflux Disease After Laparoscopic Sleeve Gastrectomy.Obesity surgery · 2021Article
- Pathophysiology of gastroesophageal reflux disease-which factors are important?Translational gastroenterology and hepatology · 2021Article
- Different Effects of Aerobic Exercise and Diaphragmatic Breathing on Lower Esophageal Sphincter Pressure and Quality of Life in Patients with Reflux: A Comparative Study.Middle East journal of digestive diseases · 2021Article
- Anti-reflux mucosal ablation (ARMA) as a new treatment for gastroesophageal reflux refractory to proton pump inhibitors: a pilot study.Endoscopy international open · 2020Article
- Surgical Anatomy of Paraesophageal Hernias.Thoracic surgery clinics · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review focuses on the pathophysiology of gastroesophageal reflux disease (GERD) and its implications for treatment. The role of the natural anti-reflux mechanism (lower esophageal sphincter, esophageal peristalsis, diaphragm, and trans-diaphragmatic pressure gradient), mucosal damage, type of refluxate, presence and size of hiatal hernia, Helicobacter pylori infection, and Barrett's esophagus are reviewed. The conclusions drawn from this review are: (1) the pathophysiology of GERD is multifactorial; (2) because of the pathophysiology of the disease, surgical therapy for GERD is the most appropriate treatment; and (3) the genesis of esophageal adenocarcinoma is associated with GERD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.