SynthesisEuropean journal of nutrition2011
Is dietary fat associated with the risk of colorectal cancer? A meta-analysis of 13 prospective cohort studies.
Synthesis in European journal of nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 6 of them syntheses that pooled it.
What it found
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Who cites it
27 citing papers in PubMed, 6 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Role of Diet in Colorectal Cancer Incidence: Umbrella Review of Meta-analyses of Prospective Observational Studies.JAMA network open · 2021Pooled it
- Dietary fatty acids and colorectal cancer risk in men: A report from the Shanghai Men's Health Study and a meta-analysis.International journal of cancer · 2021Pooled it
- Dietary Fat Intake and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies.Nutrients · 2018Pooled it
- Dietary Fat Intake and Risk of Gastric Cancer: A Meta-Analysis of Observational Studies.PloS one · 2015Pooled it
- Biospecimen long-chain N-3 PUFA and risk of colorectal cancer: a meta-analysis of data from 60,627 individuals.PloS one · 2014Pooled it
- System review and metaanalysis of the relationships between five metabolic gene polymorphisms and colorectal adenoma risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Pooled it
- Lactobacillus johnsonii Synthesizes Chenodeoxycholic Acid to Reduce Susceptibility to High-Fat Diet-Induced Colorectal Cancer.Cancer research · 2025Article
- Dietary monounsaturated fatty acids in relation to risk of gastric cancer.European journal of nutrition · 2025Article
- From surviving to thriving: How sleep, physical activity, and diet shape well-being in young adults.PloS one · 2025Article
- Review
- Dietary medium-chain fatty acids and risk of incident colorectal cancer in a predominantly low-income population: a report from the Southern Community Cohort Study.The American journal of clinical nutrition · 2024Article
- Fat and fatty acids - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2024Article
- Epidemiology beyond its limits.Science advances · 2022Article
- Dietary fat and fatty acids in relation to risk of colorectal cancer.European journal of nutrition · 2022Article
- Yogurt consumption and colorectal polyps.The British journal of nutrition · 2020Article
- Gut microbiota in colorectal cancer: mechanisms of action and clinical applications.Nature reviews. Gastroenterology & hepatology · 2019Review
- Dietary Fat-Accelerating Leptin Signaling Promotes Protumorigenic Gastric Environment in Mice.Nutrients · 2019Article
- Xenobiotics Formed during Food Processing: Their Relation with the Intestinal Microbiota and Colorectal Cancer.International journal of molecular sciences · 2019Review
- The association of diet, gut microbiota and colorectal cancer: what we eat may imply what we get.Protein & cell · 2018Review
- Evaluation of the Impact of Cancer Treatment on the Adoption and Consolidation of Pro-Health Attitudes in the Field of Cancer in Treated Patients with Colon Cancer.Journal of cancer education : the official journal of the American Association for Cancer Education · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe results of animal studies suggest there is a significant role for dietary fat in the development of colorectal cancer (CRC). However, inconsistent results have been reported by epidemiological studies. AIM OF STUDY: To evaluate the association between total dietary fat and risk of colorectal cancer development using a meta-analysis based on prospective cohort studies.
methodsPublished literature was retrieved from Medline, Embase and CNKI (China Knowledge Resource Integrated Database) databases updated to 1st May, 2009. Overall, thirteen prospective cohort studies with 3,635 cases and 459,910 participants were included.
resultsThe combined relative risk (RR) [95% confidence interval (95%CI)] for the risk of CRC was 0.99 (0.89,1.09) when the highest level of total dietary fat was versus (vs.) the lowest level. Stratified analyses according to gender, ethnicity, country and age showed that the highest level of total dietary fat did not increase the risk of CRC [RR (95%CI): 0.89 (0.77,1.03) for males; 1.09 (0.94,1.26) for females; 1.08 (0.94,1.25) for Caucasians; 0.90 (0.77,1.04) for Asians; 1.13 (0.94,1.36) for Americans; 0.92 (0.81,1.04) for individuals older than 40]. Besides those, the highest level of total fat diet also did not increase the risk of neither colon cancer [RR (95%CI): 0.96 (0.82,1.13)] nor rectal cancer [RR (95%CI):1.07 (0.63,1.82)]. Furthermore, neither animal fat nor plant fat were associated with the risk of CRC [RR (95%CI): 1.05 (0.91-1.22) for animal fat and 0.96 (0.82-1.11) for plant fat].
conclusionsThis meta-analysis suggests that dietary fat may not be associated with the increased risk of CRC. More well-designed studies with larger population performed among Asians are needed to further evaluate the associations. In addition, probable bias caused by measurement error should be noticed in this meta-analysis, and measurement error needs to be adjusted in the future studies.
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