ArticleEpilepsy currents2010
Is neuronal death necessary for acquired epileptogenesis in the immature brain?
Article in Epilepsy currents, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Microglial phagocytosis in epilepsy: Mechanisms and impact.The Journal of physiology · 2026Review
- Background suppression of electrical activity is a potential biomarker of subsequent brain injury in a rat model of neonatal hypoxia-ischemia.Journal of neurophysiology · 2022Article
- Spontaneous Recurrent Absence Seizure-like Events in Wild-Caught Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Prognostic factors of neurological outcomes in late-preterm and term infants with perinatal asphyxia.Korean journal of pediatrics · 2016Article
- Neuronal degeneration is observed in multiple regions outside the hippocampus after lithium pilocarpine-induced status epilepticus in the immature rat.Neuroscience · 2013Article
- Experimental models of status epilepticus and neuronal injury for evaluation of therapeutic interventions.International journal of molecular sciences · 2013Review
- Novel animal models of pediatric epilepsy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
- Risk factors for epilepsy in children with neonatal encephalopathy.Pediatric research · 2011Article
- Lithium pilocarpine-induced status epilepticus in postnatal day 20 rats results in greater neuronal injury in ventral versus dorsal hippocampus.Neuroscience · 2011Article
- Development of later life spontaneous seizures in a rodent model of hypoxia-induced neonatal seizures.Epilepsia · 2011Article
- Does acquired epileptogenesis in the immature brain require neuronal death.Epilepsy currents · 2011Article
- Febrile seizures research is really heating up!Epilepsy currents · 2011Article
- A 15-year epileptogenic period after perinatal brain injury.Functional neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A central question concerning acquired epileptogenesis in the immature brain is whether neuronal death is required for the development of epilepsy after a brain insult. Results from three different animal models of brain injury during early development have been used to develop the hypothesis that status epilepticus, prolonged febrile seizures, or hypoxia-induced seizures can lead to chronic epilepsy without the occurrence of neuronal death. This brief review will summarize the evidence supporting the hypothesis in each model and then critique the data and published interpretations. A case will be made that the evidence to date neither rules out the occurrence of neuronal death nor demonstrates that epileptogenesis (i.e., spontaneous recurrent seizures) has actually occurred in these animal models of acquired pediatric epilepsy. We also review evidence for the opposing hypothesis: acquired epileptogenesis in the immature brain requires, or at least often involves, neuronal death.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.