Evidence map›Paper›PMID 20697287›Full record

ReviewCurrent opinion in infectious diseases2010

Bacteroides spp. and diarrhea.

Elizabeth C Wick, Cynthia L Sears

Abstract readReview
In one paragraph

Review in Current opinion in infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 87 citations in OpenAlex.

  1. Effect of Oral Intake ofNutrients · 2022
    Trial
  2. Frontiers in immunology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elizabeth C WickDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Cynthia L Sears
Johns Hopkins Medicine · US

Funding

PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXINR01DK045496 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEARS, CYNTHIA · 1993 to 2010
$3.6M
Mechanisms of Interleukin-17 Inflammation Induced by Bacteroides fragilisR01DK080817 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEARS, CYNTHIA · 2008 to 2012
$1.7M
Pathogen of Enterotoxigenic Bacteriodes Fragilis InfectR01DK059655 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEARS, CYNTHIA · 2001 to 2003
$757k
NIDDK NIH HHS R01 DK045496NIDDK NIH HHS R01 DK059655NIDDK NIH HHS R01 DK080817
6 · The paper itself

Abstract

purpose of reviewThe purpose of this review is to describe recent progress in the understanding of the role of Bacteroides spp. in human diarrheal diseases and newer murine studies implicating certain Bacteroides spp. in colorectal cancer. RECENT

findingsBacteroides fragilis is the only strain of Bacteroides spp. associated with diarrheal disease. Toxin-producing strains of B. fragilis, termed enterotoxigenic Bacteroides fragilis (ETBF), are an established cause of diarrheal disease in people. The clinical syndrome associated with ETBF diarrheal disease encompasses abdominal pain, tenesmus and inflammatory diarrhea. Two new studies conducted in mice have further defined the chronic inflammatory response associated with ETBF infection and observed that in the multiple intestinal neoplasia mouse strain, heterozygotes for the adenomatous polyposis coli gene, ETBF infection enhances development of colonic tumors. Separate murine studies have begun to define the role of nontoxin-producing B. fragilis as a symbiont, serving possibly to protect the host from colonic inflammation. SUMMARY: B. fragilis remains the leading anaerobe in human disease. ETBF is emerging as an important cause of human diarrheal disease but additional epidemiologic studies are needed to better understand the role of ETBF human disease.

Indexed as

Adenomatous Polyposis Coli ProteinAnimalsBacterial ToxinsBacteroides fragilisBacteroides InfectionsColorectal NeoplasmsDiarrheaDisease Models, AnimalGenetic Predisposition to DiseaseHumansMicePolymorphism, GeneticVirulence FactorsAdenomatous Polyposis Coli ProteinBacterial ToxinsVirulence Factors

Identifiers

PMID20697287
PMCPMC3079340
OpenAlexW2067914794

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.