Evidence map›Paper›PMID 20697258›Full record

ReviewThe American journal of the medical sciences2010

Progress in the development of effective vaccines to prevent selected gram-positive bacterial infections.

Michael S Bronze, James B Dale

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The American journal of the medical sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Structural vaccinology to thwart antigenic variation in microbial pathogens.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michael S BronzeDivision of Infectious Diseases, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA. Michael-Bronze@ouhsc.edu
James B Dale
University of Oklahoma Health Sciences Center · US

Funding

Chemistry and Immunology of Streptococcal M ProteinsR37AI010085 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI DALE, JAMES B. · 1986 to 2010
$3.3M
Vaccine Prevention of Rheumatic FeverU01AI060592 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI DALE, JAMES B. · 2004 to 2008
$2.4M
Vaccine Prevention of Group A Streptococcal InfectionsR01AI010085 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI DALE, JAMES B. · 1985 to 2016
$2.4M
NIAID NIH HHS R01 AI010085NIAID NIH HHS R37 AI010085NIAID NIH HHS U01 AI060592
6 · The paper itself

Abstract

Infections caused by virulent Gram-positive bacteria, such as Staphylococcus aureus, group B streptococci and group A streptococci, remain significant causes of morbidity and mortality despite progress in antimicrobial therapy. Despite significant advances in the understanding of the pathogenesis of infection caused by these organisms, there are only limited strategies to prevent infection. In this article, we review efforts to develop safe and effective vaccines that would prevent infections caused by these 3 pathogens.

Indexed as

Bacterial VaccinesGram-Positive Bacterial InfectionsHumansBacterial Vaccines

Identifiers

PMID20697258
PMCPMC2935929
OpenAlexW2044768472

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.