ArticleGenome biology and evolution2010
Intergenic transposable elements are not randomly distributed in bacteria.
Article in Genome biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Insertion sequence elements associated with Staphylococcus epidermidis evolution in persistent orthopaedic device-related infections.BMC genomics · 2026Article
- Independent, ongoing clade-specific expansions of ISMicrobial genomics · 2026Article
- Emerging trends in genome integration tools for precision engineering of diverse bacterial species.Synthetic biology (Oxford, England) · 2025Review
- Article
- Deciphering the role of insertion sequences in the evolution of bacterial epidemic pathogens withMicrobial genomics · 2020Article
- Transposable Elements Mediate Adaptive Debilitation of Flagella in Experimental Escherichia coli Populations.Journal of molecular evolution · 2017Article
- Chromosomal replication dynamics and interaction with the β sliding clamp determine orientation of bacterial transposable elements.Genome biology and evolution · 2014Article
- Bacterial genome instability.Microbiology and molecular biology reviews : MMBR · 2014Review
- Insertion sequence distribution bias in Archaea.Mobile genetic elements · 2014Article
- Atypical at skew in Firmicute genomes results from selection and not from mutation.PLoS genetics · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Insertion sequences (ISs) are mobile genetic elements in bacterial genomes. In general, intergenic IS elements are probably less deleterious for their hosts than intragenic ISs, simply because they have a lower likelihood of disrupting native genes. However, since promoters, Shine-Dalgarno sequences, and transcription factor binding sites are intergenic and upstream of genes, I hypothesized that not all neighboring gene orientations (NGOs) are selectively equivalent for IS insertion. To test this, I analyzed the NGOs of all intergenic ISs in 326 fully sequenced bacterial chromosomes. Of the 116 genomes with enough IS elements for statistical analysis, 68 have significantly more ISs between convergently oriented genes than expected, and 46 have significantly fewer ISs between divergently oriented genes. This suggests that natural selection molds intergenic IS distributions because they are least intrusive between convergent gene pairs and most intrusive between divergent gene pairs.
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Registered trials
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