ArticleNeurology2010
Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus.
Article in Neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Common SNCA Genetic Variants and Parkinson's Disease Risk: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Association between alpha-synuclein (SNCA) rs11931074 variability and susceptibility to Parkinson's disease: an updated meta-analysis of 41,811 patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Pooled it
- An updated analysis with 45,078 subjects confirms the association between SNCA rs11931074 and Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Pooled it
- Associations of rs823128, rs1572931, and rs823156 polymorphisms with reduced Parkinson's disease risks.Neuroreport · 2017Pooled it
- Interaction Between Cigarette Smoking and PARK16 on Parkinson's Disease.International journal of molecular sciences · 2026Article
- Article
- The Role of Magnesium in Parkinson's Disease: Status Quo and Implications for Future Research.International journal of molecular sciences · 2024Review
- Genetic polymorphisms of bone marrow stromal cell antigen-1 (BST-1/CD157): implications for immune/inflammatory dysfunction in neuropsychiatric disorders.Frontiers in immunology · 2023Review
- Oral Supplementation with L-Carnosine Attenuates Social Recognition Deficits in CD157KO Mice via Oxytocin Release.Nutrients · 2022Article
- Somatic Mutations Detected in Parkinson Disease Could Affect Genes With a Role in Synaptic and Neuronal Processes.Frontiers in aging · 2022Article
- The effect of the PARK16 rs11240572 variant on brain structure in Parkinson's disease.Brain structure & function · 2021Article
- CD157 and Brain Immune System in (Patho)physiological Conditions: Focus on Brain Plasticity.Frontiers in immunology · 2020Review
- Parkinson's disease GWAS-linked Park16 carriers show greater motor progression.Journal of medical genetics · 2019Article
- SNPs rs11240569, rs708727, and rs823156 inInternational journal of molecular sciences · 2019Article
- BST1 rs4698412 allelic variant increases the risk of gait or balance deficits in patients with Parkinson's disease.CNS neuroscience & therapeutics · 2019Article
- The association between CD157/BST1 polymorphisms and the susceptibility of Parkinson's disease: a meta-analysis.Neuropsychiatric disease and treatment · 2019Article
- The Effects ofFrontiers in neuroscience · 2019Article
- Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells.Scientific reports · 2017Article
- An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator.BMC neuroscience · 2017Article
- S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation.Scientific reports · 2017Article
Corrections and comments
- Erratum issuedKwok, H-K [corrected to Kwok, H-H]
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA genome-wide association study (GWAS) in the Japanese population identified 2 new Parkinson disease (PD) susceptibility loci on 1q32 (PARK16) (OMIM 613164) and BST1. We analyzed single nucleotide polymorphism (SNPs) located at the GWAS-linked loci (PARK16, PARK8, PARK1, and BST1) in a Chinese population and also conducted a meta-analysis in Asians by pooling 2 independent replication studies from Japan.
methodsWe conducted an analysis of 13 SNPs associated with PD GWAS-linked loci in 2 case-control cohorts comprised of 1,349 ethnic Chinese subjects.
resultsPARK16, PARK8, and PARK1 loci but not BST1 were found to be associated with PD. PARK16 SNPs were associated with a decreased risk while PARK1 and PARK8 SNPs were associated with an increased risk of PD. A pooled analysis of our Chinese cohorts and 2 Japanese replication cohorts involving 1,366 subjects with PD and 16,669 controls revealed robust association with these 3 loci and also BST1. There was a trend toward a stronger protective effect of SNPs at the PARK16 locus in sporadic PD compared to familial cases and in older compared to younger subjects.
conclusionsOur study reaffirms the role of GWAS-linked loci in PD in Asian subjects and the strength of association is similar between Chinese and Japanese subjects. Efforts to elucidate the associated gene within PARK16 locus are warranted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.