Trial reportCirculation2010
Birth weight is a significant risk factor for incident atrial fibrillation.
Trial report in Circulation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000479 (Women's Health Study of Low-dose Aspirin and Vitamin E in Apparently Healthy Women), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Women's Health Study of Low-dose Aspirin and Vitamin E in Apparently Healthy Women
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- The Association Between High Birth Weight and Long-Term Outcomes-Implications for Assisted Reproductive Technologies: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2021Pooled it
- Birth Weight and Risk of Cardiovascular Disease Incidence in Adulthood: a Dose-Response Meta-analysis.Current atherosclerosis reports · 2020Pooled it
- Risk factors for incident atrial fibrillation with and without left atrial enlargement in women.International journal of cardiology · 2013Trial
- Birth weight, cardiovascular health, and the risk of cardiovascular disease: A longitudinal perspective from the UK biobank cohort.American journal of preventive cardiology · 2025Article
- Assessing ambient air pollution's effects on birth outcomes: a Scottish IVF cohort study (2010 -2018).Environmental health : a global access science source · 2025Article
- Demographic trends in mortality with older population due to atrial fibrillation and flutter from 1999-2020.World journal of cardiology · 2025Article
- Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association.European heart journal · 2024Article
- Opposite causal effects of birthweight on myocardial infarction and atrial fibrillation and the distinct mediating pathways: a Mendelian randomization study.Cardiovascular diabetology · 2023Article
- The Association between Birthweight and Use of Cardiovascular Medications: The Role of Health Behaviors.Journal of cardiovascular development and disease · 2023Article
- A Discussion of the Contemporary Prediction Models for Atrial Fibrillation.Medical research archives · 2023Article
- Associations of birth weight and later life lifestyle factors with risk of cardiovascular disease in the USA: A prospective cohort study.EClinicalMedicine · 2022Article
- The Risk of Atrial Fibrillation Increases with Earlier Onset of Obesity: A Mendelian Randomization Study.International journal of medical sciences · 2022Article
- Low Birth Weight Increases the Risk of Sudden Cardiac Death in the Young: A Nationwide Study of 2.2 Million People.Journal of the American Heart Association · 2021Article
- Genetic Determinants of Increased Body Mass Index Partially Mediate the Effect of Elevated Birth Weight on the Increased Risk of Atrial Fibrillation.Frontiers in cardiovascular medicine · 2021Article
- Young adults born preterm below 30 weeks of gestation and risk of QT tract prolongation.Pediatric research · 2020Article
- Genetically Determined Birthweight Associates With Atrial Fibrillation: A Mendelian Randomization Study.Circulation. Genomic and precision medicine · 2020Article
- Abnormal Atrial Activation at Surface Electrocardiogram Examination in Born Underweight Young Adults.Journal of atrial fibrillation · 2018Article
- Early Life Risk Factors for Incident Atrial Fibrillation in the Helsinki Birth Cohort Study.Journal of the American Heart Association · 2017Article
- Association between Birth Characteristics and Cardiovascular Autonomic Function at Mid-Life.PloS one · 2016Article
- Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFew if any studies have assessed the relationship between birth weight and incident atrial fibrillation (AF). METHODS AND
resultsFrom 1993 to 2009, we prospectively followed 27 982 women who were >45 years of age and free of cardiovascular disease and AF at baseline. Information on birth weight was categorized into 5 different categories: <2.5, 2.5 to 3.2, 3.2 to 3.9, 3.9 to 4.5, and >4.5 kg. The primary outcome was time to incident AF. During 14.5 years of follow-up, 735 AF events occurred. Age-adjusted incidence rates for incident AF from the lowest to the highest birth weight category were 1.45, 1.82, 1.88, 2.57, and 2.55 events per 1000 person-years of follow-up. After multivariable adjustment, hazard ratios for incident AF across increasing birth weight categories were 1.0, 1.30 (95% confidence interval [CI], 0.96 to 1.75), 1.28 (95% CI, 0.96 to 1.69), 1.70 (95% CI, 1.23 to 2.37), and 1.71 (95% CI, 1.12 to 2.61) (P for linear trend=0.002). Adding body mass index, blood pressure, and diabetes mellitus at study entry did not have a large effect on these estimates (P for linear trend=0.004). In contrast, including height in the multivariable model substantially attenuated the relationship between birth weight and AF (P for linear trend=0.17), and additional adjustment for maximum weight in young adulthood further attenuated this association (multivariable-adjusted hazard ratio across birth weight categories, 1.0, 1.27 [95% CI, 0.94 to 1.71], 1.10 [95% CI, 0.83 to 1.46], 1.41 [95% CI, 1.01 to 1.96], and 1.29 [95% CI, 0.84 to 1.98]; P for linear trend=0.23).
conclusionsBirth weight is significantly associated with incident AF among women, suggesting that early life determinants may play an important role in the pathogenesis of AF. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00000479.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.