ArticleProceedings of the National Academy of Sciences of the United States of America2010
AIDS-protective HLA-B*27/B*57 and chimpanzee MHC class I molecules target analogous conserved areas of HIV-1/SIVcpz.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Antiretroviral therapy blocks natural selection on protective and disease-susceptible HLA-B alleles in HIV-1 infection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Taxonomic variation in immune response strategies among primates.Genes and immunity · 2025Review
- TheFrontiers in immunology · 2023Article
- The influence of evolutionary history on human health and disease.Nature reviews. Genetics · 2021Review
- Similar patterns of genetic diversity and linkage disequilibrium in Western chimpanzees (Pan troglodytes verus) and humans indicate highly conserved mechanisms of MHC molecular evolution.BMC evolutionary biology · 2020Article
- The HLA A03 Supertype and SeveralJournal of virology · 2020Article
- Differences in MHC-B diversity and KIR epitopes in two populations of wild chimpanzees.Immunogenetics · 2019Article
- Limited MHC class II gene polymorphism in the West African chimpanzee is distributed maximally by haplotype diversity.Immunogenetics · 2019Article
- Two to Tango: Co-evolution of Hominid Natural Killer Cell Receptors and MHC.Frontiers in immunology · 2019Review
- Generalists and Specialists: A New View of How MHC Class I Molecules Fight Infectious Pathogens.Trends in immunology · 2018Review
- Limited MHC class I intron 2 repertoire variation in bonobos.Immunogenetics · 2017Article
- AIDS in chimpanzees: the role of MHC genes.Immunogenetics · 2017Review
- Bonobos Maintain Immune System Diversity with Three Functional Types of MHC-B.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Gorilla MHC class I gene and sequence variation in a comparative context.Immunogenetics · 2017Article
- HLA superfamily assignment is a predictor of immune response to cancer testis antigens and survival in ovarian cancer.Gynecologic oncology · 2016Article
- Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Co-evolution of the MHC class I and KIR gene families in rhesus macaques: ancestry and plasticity.Immunological reviews · 2015Review
- The Role of the Antiviral APOBEC3 Gene Family in Protecting Chimpanzees against Lentiviruses from Monkeys.PLoS pathogens · 2015Article
- Signature Patterns of MHC Diversity in Three Gombe Communities of Wild Chimpanzees Reflect Fitness in Reproduction and Immune Defense against SIVcpz.PLoS biology · 2015Article
- Immune mechanisms of vaccine induced protection against chronic hepatitis C virus infection in chimpanzees.World journal of hepatology · 2015Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the absence of treatment, most HIV-1-infected humans develop AIDS. However, a minority are long-term nonprogressors, and resistance is associated with the presence of particular HLA-B*27/B*57 molecules. In contrast, most HIV-1-infected chimpanzees do not contract AIDS. In comparison with humans, chimpanzees experienced an ancient selective sweep affecting the MHC class I repertoire. We have determined the peptide-binding properties of frequent chimpanzee MHC class I molecules, and show that, like HLA-B*27/B*57, they target similar conserved areas of HIV-1/SIV(cpz). In addition, many animals appear to possess multiple molecules targeting various conserved areas of the HIV-1/SIV(cpz) Gag protein, a quantitative aspect of the immune response that may further minimize the chance of viral escape. The functional characteristics of the contemporary chimpanzee MHC repertoire suggest that the selective sweep was caused by a lentiviral pandemic.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.