ArticleProceedings of the National Academy of Sciences of the United States of America2010
Small-molecule inducers of insulin expression in pancreatic alpha-cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 79 citations in OpenAlex.
- Metabolic reprogramming drives pancreatic β cell neogenesis from α cells.Nature chemical biology · 2026Article
- RSK signaling in myeloid malignancies: biology, disease dependency, and therapeutic targeting.Frontiers in cell and developmental biology · 2026Review
- Mitochondrial signatures shape phenotype switching and apoptosis in response to PLK1 inhibitors.Life science alliance · 2025Article
- Activation of MAP Kinase Pathway by Polyisoprenylated Cysteinyl Amide Inhibitors Causes Apoptosis and Disrupts Breast Cancer Cell Invasion.Biomedicines · 2024Article
- Stimulation of insulin secretion induced by low 4-cresol dose involves the RPS6KA3 signalling pathway.PloS one · 2024Article
- The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems.PLoS biology · 2023Article
- Therapeutic targeting of p90 ribosomal S6 kinase.Frontiers in cell and developmental biology · 2023Review
- Dissecting the molecular trajectory of fibroblast reprogramming to chemically induced mammary epithelial cells.Frontiers in cell and developmental biology · 2023Article
- Artemether treatment improves islet function and metabolic homeostasis in diabetic nonhuman primates.Journal of diabetes · 2023Article
- Review
- Review
- RSK Isoforms in Acute Myeloid Leukemia.Biomedicines · 2021Review
- Debates in Pancreatic Beta Cell Biology: Proliferation Versus Progenitor Differentiation and Transdifferentiation in Restoring β Cell Mass.Frontiers in endocrinology · 2021Review
- RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit.Oncotarget · 2020Article
- Article
- Chemical compound-based direct reprogramming for future clinical applications.Bioscience reports · 2018Review
- p90RSK Blockade Inhibits Dual BRAF and MEK Inhibitor-Resistant Melanoma by Targeting Protein Synthesis.The Journal of investigative dermatology · 2017Article
- Artemisinins Target GABACell · 2017Article
- Advances in β cell replacement and regeneration strategies for treating diabetes.The Journal of clinical investigation · 2016Review
- Stress-induced adaptive islet cell identity changes.Diabetes, obesity & metabolism · 2016Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
High-content screening for small-molecule inducers of insulin expression identified the compound BRD7389, which caused alpha-cells to adopt several morphological and gene expression features of a beta-cell state. Assay-performance profile analysis suggests kinase inhibition as a mechanism of action, and we show that biochemical and cellular inhibition of the RSK kinase family by BRD7389 is likely related to its ability induce a beta-cell-like state. BRD7389 also increases the endocrine cell content and function of donor human pancreatic islets in culture.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.