ArticleProceedings of the National Academy of Sciences of the United States of America2010
Coexpression of potato type I and II proteinase inhibitors gives cotton plants protection against insect damage in the field.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 178 citations in OpenAlex.
- Evolution, structural diversity and functional plasticity of plant derived multifunctional proteases and α-amylases inhibitors.Plant molecular biology · 2026Review
- Jasmonate signaling and prey nutrient availability trigger distinct biochemical responses in the Drosera capensis feeding cycle.Plant physiology · 2026Article
- Silenced cutters: mechanisms and effects of protease inhibition in plant-pathogen interactions.Journal of experimental botany · 2025Review
- The Potential for Trypsin Inhibitor Expression in Leaves to Convey Herbivory Deterrence in Soybean.Plants (Basel, Switzerland) · 2025Article
- Comparative Transcriptome Analysis Reveals Expression of Defense Pathways and Specific Protease Inhibitor Genes inInsects · 2025Article
- Cotton Bollworm (H. armigera) Effector PPI5 Targets FKBP17-2 to Inhibit ER Immunity and JA/SA Responses, Enhancing Insect Feeding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Comprehensive characterization of protease inhibiting gene family, cis-regulatory elements, and protein interaction network in linseed and their expression upon bud fly infestation.Scientific reports · 2024Article
- Identification and Characterization of a Trypsin Inhibitor from Fagopyrum tataricumSeeds.Applied biochemistry and biotechnology · 2024Article
- Enhanced chemical and physical defense traits in a rice cultivar showing resistance to leaffolder infestation.Crop health · 2023Article
- A constitutive serine protease inhibitor suppresses herbivore performance in tea (Horticulture research · 2023Article
- Canonical or noncanonical? Structural plasticity of serine protease-binding loops in Kunitz-STI protease inhibitors.Protein science : a publication of the Protein Society · 2023Article
- Carboxypeptidase inhibitors fromFrontiers in molecular biosciences · 2023Article
- Enhanced anti-herbivore defense of tomato plants against Spodoptera litura by their rhizosphere bacteria.BMC plant biology · 2022Article
- Impact of Rice and Potato Host Plants Is Higher on the Reproduction than Growth of Corn Strain Fall Armyworm,Insects · 2022Article
- Biotechnological Approaches for Host Plant Resistance to Insect Pests.Frontiers in genetics · 2022Review
- Pleiotropic effects of recombinant protease inhibitors in plants.Frontiers in plant science · 2022Review
- Genetic Engineering Approaches for Enhanced Insect Pest Resistance in Sugarcane.Molecular biotechnology · 2021Review
- PINIR: a comprehensive information resource for Pin-II type protease inhibitors.BMC plant biology · 2021Article
- Effects of a Reserve Protein onMolecules (Basel, Switzerland) · 2020Article
- Local Responses and Systemic Induced Resistance Mediated by Ectomycorrhizal Fungi.Frontiers in plant science · 2020Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Potato type I and II serine protease inhibitors are produced by solanaceous plants as a defense mechanism against insects and microbes. Nicotiana alata proteinase inhibitor (NaPI) is a multidomain potato type II inhibitor (pin II) that is produced at high levels in the female reproductive tissues of the ornamental tobacco, Nicotiana alata. The individual inhibitory domains of NaPI target the major classes of digestive enzymes, trypsin and chymotrypsin, in the gut of lepidopteran larval pests. Although consumption of NaPI dramatically reduced the growth and development of a major insect pest, Helicoverpa punctigera, we discovered that surviving larvae had high levels of chymotrypsin activity resistant to inhibition by NaPI. We found a potato type I inhibitor, Solanum tuberosum potato type I inhibitor (StPin1A), was a strong inhibitor of the NaPI-resistant chymotrypsin activity. The combined inhibitory effect of NaPI and StPin1A on H. armigera larval growth in the laboratory was reflected in the increased yield of cotton bolls in field trials of transgenic plants expressing both inhibitors. Better crop protection thus is achieved using combinations of inhibitors in which one class of proteinase inhibitor is used to match the genetic capacity of an insect to adapt to a second class of proteinase inhibitor.
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