Evidence map›Paper›PMID 20696871›Full record

ArticleAntimicrobial agents and chemotherapy2010

Overexpression of the adeB gene in clinical isolates of tigecycline-nonsusceptible Acinetobacter baumannii without insertion mutations in adeRS.

Jun-Ren Sun, Ming-Chin Chan, Tein-Yao Chang, Wei-Yao Wang, Tzong-Shi Chiueh

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Structural analysis of resistance-nodulation cell division transporters.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  2. Molecular epidemiology and resistance mechanisms of tigecycline-non-susceptible Acinetobacter baumannii isolated from a tertiary care hospital in Chongqing, China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
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  7. Review
  8. Phenotype microarray analysis of the AdeRS two-component system in Acinetobacter baumannii.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017
    Article
  9. Review
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  14. Review
  15. AdeRS combination codes differentiate the response to efflux pump inhibitors in tigecycline-resistant isolates of extensively drug-resistant Acinetobacter baumannii.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jun-Ren SunDivision of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, 325 Section 2 Cheng-Kung Road, Neihu, Taipei, Taiwan.
Ming-Chin Chan
Tein-Yao Chang
Wei-Yao Wang
Tzong-Shi Chiueh

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thirteen clinical isolates of multidrug-resistant Acinetobacter baumannii resistant to carbapenems (MRAB-C) with tigecycline nonsusceptibility were collected from individual patients in this study. None of the 13 isolates shared the same strain characteristics in molecular typing. All of them showed increased adeB transcription, as predicted. However, none of these tigecycline-nonsusceptible MRAB-C isolates were found to possess previously known adeRS mutations. Upregulation of adeB transcription may result from cross stimulation by other mechanisms.

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAgedAged, 80 and overBacterial ProteinsCarbapenemsDrug Resistance, BacterialFemaleHumansMaleMembrane Transport ProteinsMiddle AgedMinocyclineMolecular Sequence DataMutagenesis, InsertionalReverse Transcriptase Polymerase Chain ReactionAdeB protein, Acinetobacter baumanniiBacterial ProteinsCarbapenemsMembrane Transport ProteinsMinocyclineTigecycline

Identifiers

PMID20696871
PMCPMC2976115

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.