ReviewMolecular and cellular biology2010
Architectural epigenetics: mitotic retention of mammalian transcriptional regulatory information.
Review in Molecular and cellular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- The cardiovascular and hypothalamus-pituitary-adrenal axis response to stress is controlled by glucocorticoid receptor sequence variants and promoter methylation.Clinical epigenetics · 2016Trial
- Acetylation-Mediated Epigenetic Consequences for Biological Control and Cancer.Results and problems in cell differentiation · 2025Review
- Article
- Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of Plasmodium falciparum.International journal of biological macromolecules · 2022Article
- LINE-1 and Alu methylation signatures in autism spectrum disorder and their associations with the expression of autism-related genes.Scientific reports · 2022Article
- A new role for the ginsenoside RG3 in antiaging via mitochondria function in ultraviolet-irradiated human dermal fibroblasts.Journal of ginseng research · 2019Article
- Nuclear organization mediates cancer-compromised genetic and epigenetic control.Advances in biological regulation · 2018Review
- A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- RING1A and BMI1 bookmark active genes via ubiquitination of chromatin-associated proteins.Nucleic acids research · 2016Article
- Identifying and functionally characterizing tissue-specific and ubiquitously expressed human lncRNAs.Oncotarget · 2016Article
- Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells.BMC genomics · 2015Article
- Characterization of the IGF2 Imprinted Gene Methylation Status in Bovine Oocytes during Folliculogenesis.PloS one · 2015Article
- Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain.FEBS letters · 2014Article
- Molecular insights into the recognition of N-terminal histone modifications by the BRPF1 bromodomain.Journal of molecular biology · 2014Article
- Altered histone modifications in gliomas.Brain tumor research and treatment · 2014Review
- Localized, non-random differences in chromatin accessibility between homologous metaphase chromosomes.Molecular cytogenetics · 2014Article
- NFATc1 and NFATc2 repress spontaneous osteoarthritis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit.Cell cycle (Georgetown, Tex.) · 2013Article
- Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci.Nucleic acids research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 3 countries.
Funding
Abstract
Epigenetic regulatory information must be retained during mammalian cell division to sustain phenotype-specific and physiologically responsive gene expression in the progeny cells. Histone modifications, DNA methylation, and RNA-mediated silencing are well-defined epigenetic mechanisms that control the cellular phenotype by regulating gene expression. Recent results suggest that the mitotic retention of nuclease hypersensitivity, selective histone marks, as well as the lineage-specific transcription factor occupancy of promoter elements contribute to the epigenetic control of sustained cellular identity in progeny cells. We propose that these mitotic epigenetic signatures collectively constitute architectural epigenetics, a novel and essential mechanism that conveys regulatory information to sustain the control of phenotype and proliferation in progeny cells by bookmarking genes for activation or suppression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.