ArticleThe American journal of pathology2010
CD34 is required for infiltration of eosinophils into the colon and pathology associated with DSS-induced ulcerative colitis.
Article in The American journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- CD34 Protein: Its expression and function in inflammation.Cell and tissue research · 2023Review
- Role of CD34 in inflammatory bowel disease.Frontiers in physiology · 2023Review
- Potent CCR3 Receptor Antagonist, SB328437, Suppresses Colonic Eosinophil Chemotaxis and Inflammation in theInternational journal of molecular sciences · 2022Article
- Inhibition of Prolyl Oligopeptidase Prevents Consequences of Reperfusion following Intestinal Ischemia.Biomedicines · 2021Article
- Prognostic value of CD34 expression status in patients with myxofibrosarcomas and undifferentiated pleomorphic sarcomas.Scientific reports · 2021Article
- Transcriptional Profiling of Mouse Eosinophils Identifies Distinct Gene Signatures Following Cellular Activation.Frontiers in immunology · 2021Article
- Morphological Estimation of Cellularity on Neo-Adjuvant Treated Breast Cancer Histological Images.Journal of imaging · 2020Article
- The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3Frontiers in immunology · 2019Article
- Transcriptome profiling of mouse colonic eosinophils reveals a key role for eosinophils in the induction of s100a8 and s100a9 in mucosal healing.Scientific reports · 2017Article
- CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.PloS one · 2016Article
- Eosinophils in Gastrointestinal Disorders: Eosinophilic Gastrointestinal Diseases, Celiac Disease, Inflammatory Bowel Diseases, and Parasitic Infections.Immunology and allergy clinics of North America · 2015Review
- In situ hematopoiesis: a regulator of TH2 cytokine-mediated immunity and inflammation at mucosal surfaces.Mucosal immunology · 2015Review
- Gingko biloba extract (Ginaton) ameliorates dextran sulfate sodium (DSS)-induced acute experimental colitis in mice via reducing IL-6/STAT3 and IL-23/IL-17.International journal of clinical and experimental medicine · 2015Article
- Accumulation of eosinophils in the infundibulum of the bovine oviduct just after ovulation.The Journal of veterinary medical science · 2014Article
- Single low-dose rHuIL-12 safely triggers multilineage hematopoietic and immune-mediated effects.Experimental hematology & oncology · 2014Article
- A familiar stranger: CD34 expression and putative functions in SVF cells of adipose tissue.World journal of stem cells · 2013Article
- Article
- IL-7Rα and L-selectin, but not CD103 or CD34, are required for murine peanut-induced anaphylaxis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2012Article
- CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration.Stem cells (Dayton, Ohio) · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Eosinophil migration into the gut and the release of granular mediators plays a critical role in the pathogenesis of inflammatory bowel diseases, including ulcerative colitis. We recently demonstrated that eosinophil migration into the lung requires cell surface expression of the sialomucin CD34 on mast cells and eosinophils in an asthma model. Based on these findings, we investigated a similar role for CD34 in the migration of eosinophils and other inflammatory cells into the colon as well as explored the effects of CD34 ablation on disease development in a dextran sulfate sodium-induced model of ulcerative colitis. Our findings demonstrate decreased disease severity in dextran sulfate sodium-treated Cd34(-/-) mice, as assessed by weight loss, diarrhea, bleeding, colon shortening and tissue pathology, compared with wild-type controls. CD34 was predominantly expressed on eosinophils within inflamed colon tissues, and Cd34(-/-) animals exhibited drastically reduced colon eosinophil infiltration. Using chimeric animals, we demonstrated that decreased disease pathology resulted from loss of CD34 from bone marrow-derived cells and that eosinophilia in Cd34(-/-)IL5(Tg) animals was sufficient to overcome protection from disease. In addition, we demonstrated a decrease in peripheral blood eosinophil numbers following dextran sulfate sodium treatment. These findings demonstrate that CD34 was expressed on colon-infiltrating eosinophils and played a role in eosinophil migration. Further, our findings suggest CD34 is required for efficient eosinophil migration, but not proliferation or expansion, in the development of ulcerative colitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.