ArticlePediatrics2010
Role of prenatal characteristics and early growth on pubertal attainment of British girls.
Article in Pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Association of prenatal and childhood environment smoking exposure with puberty timing: a systematic review and meta-analysis.Environmental health and preventive medicine · 2018Pooled it
- Nongenetic determinants of age at menarche: a systematic review.BioMed research international · 2014Pooled it
- Association of Infant Physical Development and Rapid Growth With Pubertal Onset Among Girls in Rural China.JAMA network open · 2021Trial
- Early-life programming of hypothalamic circuits by maternal obesity: implications for neuroendocrine disorders.Reviews in endocrine & metabolic disorders · 2026Review
- Early Postnatal Growth and Pubertal Timing: An Ultrasound-Based Study of Breast and Testicular Development.Journal of the Endocrine Society · 2026Article
- Timing of puberty in girls and serum polycyclic aromatic hydrocarbon (PAH)-albumin adduct levels: the California PAH Study.Journal of exposure science & environmental epidemiology · 2025Article
- Puberty, but not precocious puberty is influenced by weight gain in the first years of life.Endocrine · 2025Article
- Increase of astrocyte apposition on GnRH neurons in early puberty onset induced by high fat diet.Journal of neuroendocrinology · 2025Article
- Associations of fetal and infant growth with pubertal timing.Archives of disease in childhood · 2025Article
- The role of adipose tissue in puberty and reproductive health.Frontiers in endocrinology · 2025Review
- Earlier Menarche in Greek Girls Born by Caesarean Section: A Case-Control Study.Journal of clinical medicine · 2024Article
- Article
- Pubertal timing: A life course pathway linking early life risk to adulthood cardiometabolic health.PloS one · 2024Article
- Association of screen exposure/sedentary behavior and precocious puberty/early puberty.Frontiers in pediatrics · 2024Article
- Maternal and prenatal factors and age at thelarche in the LEGACY Girls Study cohort: implications for breast cancer risk.International journal of epidemiology · 2023Article
- Discrete-time Survival Analysis of Risk Factors for Early Menarche in Korean Schoolgirls.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2023Article
- Effects of Elevated Maternal Adiposity on Offspring Reproductive Health: A Perspective From Epidemiologic Studies.Journal of the Endocrine Society · 2022Review
- Associations between infant growth and pubertal onset timing in a multiethnic prospective cohort of girls.BMC pediatrics · 2022Article
- Retrospective longitudinal analysis of the effects of postnatal weight gain on the timing and tempo of puberty and menarche in a cohort of Italian girls.Italian journal of pediatrics · 2022Article
- Analysis of Early-Life Growth and Age at Pubertal Onset in US Children.JAMA network open · 2022Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesThe objective of this study was to explore the influence of maternal prenatal characteristics and behaviors and of weight and BMI gain during early childhood on the timing of various puberty outcomes in girls who were enrolled in the Avon Longitudinal Study of Parents and Children.
methodsRepeated self-assessments of pubertal development were obtained from approximately 4000 girls between the ages of 8 and 14. Data on prenatal characteristics and weight at birth and 2, 9, and 20 months of age were obtained from questionnaires, birth records, and clinic visits. Infants' weights were converted to weight-for-age and BMI SD scores (SDSs; z scores), and change values were obtained for the 0- to 20-month and other intervals within that age range. We used parametric survival models to estimate associations with age of entry into Tanner stages of breast and pubic hair and menarche.
resultsMaternal initiation of menarche at age<12, smoking during pregnancy, and primiparity were associated with earlier puberty. A 1-unit increase in the weight SDS change values for the 0- to 20-month age interval was associated with earlier ages of entry into pubertal outcomes (0.19-0.31 years). Increases in the BMI SDS change values were also associated with earlier entry into pubertal outcomes (0.07-0.11 years).
conclusionsMany of the maternal prenatal characteristics and weight and BMI gain during infancy seemed to have similar influences across different puberty outcomes. Either such early factors have comparable influences on each of the hormonal processes involved in puberty, or processes are linked and awakening of 1 aspect triggers the others.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.