ArticleThe Journal of experimental medicine2010
Distinct contracted conformations of the Tcra/Tcrd locus during Tcra and Tcrd recombination.
Article in The Journal of experimental medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Promoter- and enhancer-dependent cohesin loading initiates chromosome looping to fold Tcrb loci for long-range recombination.Cell reports · 2025Article
- Locus folding mechanisms determine modes of antigen receptor gene assembly.The Journal of experimental medicine · 2024Article
- Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire.The Journal of experimental medicine · 2022Article
- Regulation of T-cell Receptor Gene Expression by Three-Dimensional Locus Conformation and Enhancer Function.International journal of molecular sciences · 2020Review
- Genome Topology Control of Antigen Receptor Gene Assembly.Journal of immunology (Baltimore, Md. : 1950) · 2020Review
- Enhancers as regulators of antigen receptor loci three-dimensional chromatin structure.Transcription · 2020Review
- New insights emerge as antibody repertoire diversification meets chromosome conformation.F1000Research · 2019Review
- Article
- Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci.Frontiers in immunology · 2018Article
- Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire.Cell reports · 2017Article
- An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires.Nature immunology · 2015Article
- Domain-Specific and Stage-Intrinsic Changes in Tcrb Conformation during Thymocyte Development.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.The Journal of experimental medicine · 2015Article
- CTCF and ncRNA Regulate the Three-Dimensional Structure of Antigen Receptor Loci to Facilitate V(D)J Recombination.Frontiers in immunology · 2014Review
- Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'.Immunology · 2013Review
- Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci.Journal of immunology (Baltimore, Md. : 1950) · 2013Review
- Ikaros promotes rearrangement of TCR α genes in an Ikaros null thymoma cell line.European journal of immunology · 2013Article
- Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Studies have suggested that antigen receptor loci adopt contracted conformations to promote long-distance interactions between gene segments during V(D)J recombination. The Tcra/Tcrd locus is unique because it undergoes highly divergent Tcrd and Tcra recombination programs in CD4(-)CD8(-) double negative (DN) and CD4(+)CD8(+) double positive (DP) thymocytes, respectively. Using three-dimensional fluorescence in situ hybridization, we asked whether these divergent recombination programs are supported by distinct conformational states of the Tcra/Tcrd locus. We found that the 3' portion of the locus is contracted in DN and DP thymocytes but not in B cells. Remarkably, the 5' portion of the locus is contracted in DN thymocytes but is decontracted in DP thymocytes. We propose that the fully contracted conformation in DN thymocytes allows Tcrd rearrangements involving V(delta) gene segments distributed over 1 Mb, whereas the unique 3'-contracted, 5'-decontracted conformation in DP thymocytes biases initial Tcra rearrangements to the most 3' of the available V(alpha) gene segments. This would maintain a large pool of distal 5' V(alpha) gene segments for subsequent rounds of recombination. Thus, distinct contracted conformations of the Tcra/Tcrd locus may facilitate a transition from a Tcrd to a Tcra mode of recombination during thymocyte development.
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