Evidence map›Paper›PMID 20696319›Full record

ArticleProgress in brain research2010

The role of dopamine in modulating the structure and function of striatal circuits.

D James Surmeier, Weixing Shen, Michelle Day, Tracy Gertler, Savio Chan, Xianyong Tian, Joshua L Plotkin

Open access · greenAbstract read
In one paragraph

Article in Progress in brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. PEDOT/CNT Flexible MEAs Reveal New Insights into the Clock Gene's Role in Dopamine Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

D James SurmeierDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. j-surmeier@northwestern.edu
Weixing Shen
Michelle Day
Tracy Gertler
Savio Chan
Xianyong Tian
Joshua L Plotkin
Northwestern University · US

Funding

DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUMR37NS034696 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DALTON JAMES SURMEIER · 2001 to 2026
$7.3M
Dopaminergic and Muscarinic Signaling in the StriatumR01NS034696 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SURMEIER, DALTON JAMES · 1996 to 2018
$4.3M
DOPAMINERGIC SIGNALING IN THE NUCLEUS ACCUMBENSR01DA012958 · NIDA · NORTHWESTERN UNIVERSITY · PI SURMEIER, DALTON JAMES · 2000 to 2004
$1.3M
NIDA NIH HHS R01 DA012958NINDS NIH HHS NS34696NINDS NIH HHS R01 NS034696NINDS NIH HHS R37 NS034696
6 · The paper itself

Abstract

Dopamine (DA) is a key regulator of action selection and associative learning. The striatum has long been thought to be a major locus of DA action in this process. Although all striatal cell types express G protein-coupled receptors for DA, the effects of DA on principal medium spiny neurons (MSNs) understandably have received the most attention. In the two principal classes of MSN, DA receptor expression diverges, with striatonigral MSNs robustly expressing D(1) receptors and striatopallidal MSNs expressing D(2) receptors. In the last couple of years, our understanding of how these receptors and the intracellular signalling cascades that they couple to modulate dendritic physiology and synaptic plasticity has rapidly expanded, fuelled in large measure by the development of new optical and genetic tools. These tools also have enabled a rapid expansion of our understanding of the striatal adaptations in models of Parkinson's disease. This chapter highlights some of the major advances in these areas.

Indexed as

Neuronal PlasticityAnimalsCorpus StriatumDendritic SpinesDopamineHumansMiceMice, TransgenicNeuronsParkinson DiseaseReceptors, Dopamine D1Receptors, Dopamine D2DopamineReceptors, Dopamine D1Receptors, Dopamine D2

Identifiers

PMID20696319
PMCPMC4431764
OpenAlexW1485993153

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.