ArticleProgress in brain research2010
Intracellular signalling pathways in dopamine cell death and axonal degeneration.
Article in Progress in brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Dopamine Activates the D1R-ZnCellular and molecular neurobiology · 2023Article
- Diverse midbrain dopaminergic neuron subtypes and implications for complex clinical symptoms of Parkinson's disease.Ageing and neurodegenerative diseases · 2021Article
- Function and Regulation of ALDH1A1-Positive Nigrostriatal Dopaminergic Neurons in Motor Control and Parkinson's Disease.Frontiers in neural circuits · 2021Review
- Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning.Cell reports · 2019Article
- Nanodelivery of Cerebrolysin and Rearing in Enriched Environment Induce Neuroprotective Effects in a Preclinical Rat Model of Parkinson's Disease.Molecular neurobiology · 2018Article
- Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models.Disease models & mechanisms · 2017Article
- Use of genetically modified mesenchymal stem cells to treat neurodegenerative diseases.International journal of molecular sciences · 2014Review
- Validation of nigrostriatal positron emission tomography measures: critical limits.Annals of neurology · 2013Article
- Article
- Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease.Brain : a journal of neurology · 2012Article
- PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice.Brain : a journal of neurology · 2012Article
- Programmed cell death in Parkinson's disease.Cold Spring Harbor perspectives in medicine · 2012Review
- Axonal degeneration as a therapeutic target in the CNS.Cell and tissue research · 2012Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The pathways of programmed cell death (PCD) are now understood in extraordinary detail at the molecular level. Although much evidence suggests that they are likely to play a role in Parkinson's disease (PD), the precise nature of that role remains unknown. Two pathways of cell death that are especially well characterized are cyclin-dependent kinase 5-mediated phosphorylation of myocyte enhancer factor 2 and the mitogen-activated protein kinase signalling cascade. Although blockade of these pathways in animals has achieved a truly remarkable degree of neuroprotection of the neuron cell soma, it has not achieved protection of axons. Thus, there is a need to explore beyond the canonical pathways of PCD and investigate mechanisms of axon destruction. We also need to move beyond the narrow classic concept that the mechanisms of PCD are activated exclusively 'downstream', following cellular injury. Studies in the genetics of PD suggest that in some forms of the disease, activation may be an early 'upstream' event. Additionally, recent observations suggest that cell death in some contexts may not be initiated by injury, but instead by a failure of intrinsic cell survival signalling. These new points of view offer new opportunities for molecular targeting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.