Evidence map›Paper›PMID 20696168›Full record

SynthesisGastroenterology2011

Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome.

Kirsten Tillisch, Emeran A Mayer, Jennifer S Labus

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 207 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 13 pooled it
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

207 citing papers in PubMed, 13 syntheses or guidelines pooled it, 407 citations in OpenAlex.

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147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kirsten TillischCenter for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA.
Emeran A Mayer
Jennifer S Labus
University of California, Los Angeles · US

Funding

Women's Health and Functional Visceral Disorders CenterP50DK064539 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 2002 to 2017
$17.5M
PERCEPTION AND MODULATION OF VISCERAL SENSATIONSR01DK048351 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 1996 to 2019
$8.2M
Mind/Brain/Body Interactions in Stress-Related DisordersR24AT002681 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 2004 to 2008
$4.6M
Central and Peripheral Autonomic Responses in Irritable Bowel SyndromeK23DK073451 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TILLISCH, KIRSTEN · 2006 to 2010
$625k
Effective connectivity of central response to Irritable Bowel Syndrome (IBS)K08DK071626 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LABUS, JENNIFER S · 2006 to 2010
$607k
NCCIH NIH HHS R24 AT 00268NCCIH NIH HHS R24 AT002681NIDDK NIH HHS DK 48351NIDDK NIH HHS K08 DK 071626NIDDK NIH HHS K08 DK071626NIDDK NIH HHS K23 DK073451NIDDK NIH HHS P50 DK064539NIDDK NIH HHS P50 DK 64530NIDDK NIH HHS R01 DK048351
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe responsiveness of the central nervous system is altered in patients with irritable bowel syndrome (IBS). However, because of variations in experimental paradigms, analytic techniques, and reporting practices, little consensus exists on brain responses to visceral stimulation. We aimed to identify brain regions consistently activated by supraliminal rectal stimulation in IBS patients and healthy subjects (controls) by performing a quantitative meta-analysis of published studies.

methodsSignificant foci from within-group statistical parametric maps were extracted from published neuroimaging studies that employed rectal distension. Voxel-based activation likelihood estimation was applied, pooling the results and comparing them across groups.

resultsAcross studies, there was consistent activation in regions associated with visceral afferent processing (ie, thalamus, insula, anterior midcingulate) among IBS patients and controls, but considerable differences in the extent and specific location of foci. IBS patients differed from controls in that there were more consistent activations in regions associated with emotional arousal (pregenual anterior cingulate cortex, amygdala) and activation of a midbrain cluster, a region playing a role in endogenous pain modulation. Controls showed more consistent activation of the medial and lateral prefrontal cortex.

conclusionsPatients with IBS have greater engagement of regions associated with emotional arousal and endogenous pain modulation, but similar activation of regions involved in processing of visceral afferent information. Controls have greater engagement of cognitive modulatory regions. These results support a role for central nervous system dysregulation in IBS. These findings provide specific targets for guiding development of future neuroimaging protocols to more clearly define altered brain-gut interactions in IBS.

Indexed as

Brain MappingBrainFemaleHumansIrritable Bowel SyndromeMaleModels, StatisticalPainRectum

Identifiers

PMID20696168
PMCPMC3253553
OpenAlexW2064638321

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.