Evidence map›Paper›PMID 20696139›Full record

ReviewBiochemical pharmacology2010

Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases.

Bharat B Aggarwal, Chitra Sundaram, Seema Prasad, Ramaswamy Kannappan

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemical pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04491383 (Tocotrienols in Parkinson's Disease), which is not on this map. Cited by 215 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
215citing papers in PubMed, 4 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04491383 phase2active not recruitingnot on this mapstarted 2021, after this paper: background citation

Tocotrienols in Parkinson's Disease (PD): A Pilot, Randomised, Placebo-controlled Trial

TypeinterventionalSponsorNational Neuroscience InstituteRan2021 to 2027Enrolled100ConditionsNeuro-Degenerative Disease, Parkinson DiseaseArmsTocovid Suprabio (HOV-12020), Placebo
3 · Its place in the literature

Who cites it

215 citing papers in PubMed, 4 syntheses or guidelines pooled it, 560 citations in OpenAlex.

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155 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bharat B AggarwalCytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX 77030, USA. aggarwal@mdanderson.org
Chitra Sundaram
Seema Prasad
Ramaswamy Kannappan
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
TARGETING NF-KB ACTIVATION IN REGULATION OF SYMPTOMS IN PATIENTS WITH MULTIPLEP01CA124787 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI REUBEN, JAMES MARTIN · 2008 to 2012
$10.6M
TRIAL OF CELECOXIB IN LUNG CANCER CHEMOPREVENTIONP01CA091844 · NCI · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI HONG, WAUN KI · 2001 to 2005
$8.2M
NCI NIH HHS CA-124787-01A2NCI NIH HHS CA-16 672NCI NIH HHS P01 CA091844NCI NIH HHS P01 CA124787
6 · The paper itself

Abstract

Initially discovered in 1938 as a "fertility factor," vitamin E now refers to eight different isoforms that belong to two categories, four saturated analogues (α, β, γ, and δ) called tocopherols and four unsaturated analogues referred to as tocotrienols. While the tocopherols have been investigated extensively, little is known about the tocotrienols. Very limited studies suggest that both the molecular and therapeutic targets of the tocotrienols are distinct from those of the tocopherols. For instance, suppression of inflammatory transcription factor NF-κB, which is closely linked to tumorigenesis and inhibition of HMG-CoA reductase, mammalian DNA polymerases and certain protein tyrosine kinases, is unique to the tocotrienols. This review examines in detail the molecular targets of the tocotrienols and their roles in cancer, bone resorption, diabetes, and cardiovascular and neurological diseases at both preclinical and clinical levels. As disappointment with the therapeutic value of the tocopherols grows, the potential of these novel vitamin E analogues awaits further investigation.

Indexed as

AnimalsAntineoplastic AgentsAntioxidantsChronic DiseaseDrug Delivery SystemsHumansNeoplasmsTocotrienolsVitamin EAntineoplastic AgentsAntioxidantsTocotrienolsVitamin E

Identifiers

PMID20696139
PMCPMC2956867
OpenAlexW2068560722

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.