ArticleInfection control and hospital epidemiology2010
Multicenter study of Clostridium difficile infection rates from 2000 to 2006.
Article in Infection control and hospital epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Incidence and Outcomes Associated With Clostridium difficile Infections: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- Global burden ofJournal of global health · 2019Pooled it
- Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Guideline
- Proton pump inhibitors therapy and risk of Clostridium difficile infection: Systematic review and meta-analysis.World journal of gastroenterology · 2017Pooled it
- Dominance of toxigenicFrontiers in microbiology · 2025Article
- Strategies to preventInfection control and hospital epidemiology · 2023Article
- Article
- Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients: A multicenter experience.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
- Community-acquired Clostridium difficile infection in Serbian pediatric population.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Attributable Healthcare Resource Utilization and Costs for Patients With Primary and Recurrent Clostridium difficile Infection in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Observational
- Adherence to clinical practice guidelines for the management of Clostridium difficile infection in Japan: a multicenter retrospective study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Observational
- Epidemiological and economic burden of Clostridium difficile in the United States: estimates from a modeling approach.BMC infectious diseases · 2016Article
- The burden of clostridium difficile infection: estimates of the incidence of CDI from U.S. Administrative databases.BMC infectious diseases · 2016Article
- Epidemiology of Clostridium difficile infection: results of a hospital-based study in Krakow, Poland.Epidemiology and infection · 2015Article
- Review
- Burden of Clostridium difficile infection between 2010 and 2013: Trends and outcomes from an academic center in Eastern Europe.World journal of gastroenterology · 2015Article
- Environmental transmission of Clostridium difficile: association between hospital room size and C. difficile Infection.Infection control and hospital epidemiology · 2015Article
- Article
- Infectious causes of necrotizing enterocolitis.Clinics in perinatology · 2015Review
- Postoperative burden of hospital-acquired Clostridium difficile infection.Infection control and hospital epidemiology · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveTo compare incidence rates of Clostridium difficile infection (CDI) during a 6-year period among 5 geographically diverse academic medical centers across the United States by use of recommended standardized surveillance definitions of CDI that incorporate recent information on healthcare facility (HCF) exposure.
methodsData on C. difficile toxin assay results and dates of hospital admission and discharge were collected from electronic databases. Chart review was performed for patients with a positive C. difficile toxin assay result who were identified within 48 hours after hospital admission to determine whether they had any HCF exposure during the 90 days prior to their hospital admission. CDI cases, defined as any inpatient with a stool toxin assay positive for C. difficile, were categorized into 5 surveillance definitions based on recent HCF exposure. Annual CDI rates were calculated and evaluated by use of the chi(2) test for trend and the chi(2) summary test.
resultsDuring the study period, there were significant increases in the overall incidence rates of HCF-onset, HCF-associated CDI (from 7.0 to 8.5 cases per 10,000 patient-days; P < .001); community-onset, HCF-associated CDI attributed to a study hospital (from 1.1 to 1.3 cases per 10,000 patient-days; P = .003); and community-onset, HCF-associated CDI not attributed to a study hospital (from 0.8 to 1.5 cases per 1,000 admissions overall; P < .001). For each surveillance definition of CDI, there were significant differences in the total incidence rate between HCFs.
conclusionsThe increasing incidence rates of CDI over time and across healthcare institutions and the correlation of CDI incidence in different surveillance categories suggest that CDI may be a regional problem and not isolated to a single HCF within a community.
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